Genetic regulation of osteoclast development and function (Q29617421)

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6 November 2019

review article

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title

Genetic regulation of osteoclast development and function (English)

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30 April 2017

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6 November 2019

1

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6 November 2019

author name string

F Patrick Ross

series ordinal

2

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6 November 2019

language of work or name

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30 April 2017

publication date

1 August 2003

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6 November 2019

published in

Nature Reviews Genetics

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6 November 2019

volume

4

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6 November 2019

page(s)

638-649

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6 November 2019

issue

8

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30 April 2017

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Osteoclastic bone resorption by a polarized vacuolar proton pump

6 November 2019

cites work

1 reference

Successful bone-marrow transplantation for infantile malignant osteopetrosis.

31 March 2020

1 reference

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells

31 March 2020

1 reference

Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification

31 March 2020

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Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.

31 March 2020

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Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.

31 March 2020

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Bone Resorption Restored in Osteopetrotic Mice by Transplants of Normal Bone Marrow and Spleen Cells

31 March 2020

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Spleen Cells Transmit Osteopetrosis in Mice

31 March 2020

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Fusion disability of embryonic osteoclast precursor cells and macrophages in the microphthalmic osteopetrotic mouse

31 March 2020

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The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts

31 March 2020

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

31 March 2020

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Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences.

31 March 2020

1 reference

Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3.

31 March 2020

1 reference

Insight into the microphthalmia gene

31 March 2020

1 reference

Bone metabolism in the osteopetrotic rat mutation microphthalmia blanc

31 March 2020

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A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis

31 March 2020

1 reference

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

31 March 2020

1 reference

Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation

31 March 2020

1 reference

Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption

31 March 2020

1 reference

Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts

31 March 2020

1 reference

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

31 March 2020

1 reference

Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function

31 March 2020

1 reference

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

31 March 2020

1 reference

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

31 March 2020

1 reference

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

31 March 2020

1 reference

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

31 March 2020

1 reference

Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts

31 March 2020

1 reference

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

31 March 2020

1 reference

RANKing the importance of measles virus in Paget's disease

31 March 2020

1 reference

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

31 March 2020

1 reference

The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily

31 March 2020

1 reference

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

31 March 2020

1 reference

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

31 March 2020

1 reference

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

31 March 2020

1 reference

Distinct molecular mechanism for initiating TRAF6 signalling

31 March 2020

1 reference

The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.

31 March 2020

1 reference

Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator

31 March 2020

1 reference

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

31 March 2020

1 reference

Requirement for NF-kappaB in osteoclast and B-cell development

31 March 2020

1 reference

Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1

31 March 2020

1 reference

Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts

31 March 2020

1 reference

TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis

31 March 2020

1 reference

JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

31 March 2020

1 reference

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

31 March 2020

1 reference

Bifurcation of osteoclasts and dendritic cells from common progenitors

31 March 2020

1 reference

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

31 March 2020

1 reference

Fra-1 replaces c-Fos-dependent functions in mice

31 March 2020

1 reference

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

31 March 2020

1 reference

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

31 March 2020

1 reference

Perspectives: Osteoclast adhesion and resorption: The role of podosomes

31 March 2020

1 reference

A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function

31 March 2020

1 reference

c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation

31 March 2020

1 reference

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

31 March 2020

1 reference

Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2.

31 March 2020

1 reference

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

31 March 2020

1 reference

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

31 March 2020

1 reference

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

31 March 2020

1 reference

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

31 March 2020

1 reference

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

31 March 2020

1 reference

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

31 March 2020

1 reference

Bone resorption by osteoclasts

31 March 2020

1 reference

Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification

31 March 2020

1 reference

Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis

31 March 2020

1 reference

Novel mutations in the a3 subunit of vacuolar H(+)-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis

31 March 2020

1 reference

Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis

31 March 2020

1 reference

The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants

31 March 2020

1 reference

Substrate recognition by osteoclast precursors induces C-src/microtubule association.

31 March 2020

1 reference

Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption

31 March 2020

1 reference

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man

31 March 2020

1 reference

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

31 March 2020

1 reference

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

31 March 2020

1 reference

Determination of bone markers in pycnodysostosis: effects of cathepsin K deficiency on bone matrix degradation.

31 March 2020

1 reference

Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family

31 March 2020

1 reference

Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

31 March 2020

1 reference

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

31 March 2020

1 reference

Cathepsin K, osteoclastic resorption, and osteoporosis therapy

31 March 2020

1 reference

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.

31 March 2020

1 reference

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

31 March 2020

1 reference

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

31 March 2020

1 reference

Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity

31 March 2020

1 reference

Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis

31 March 2020

1 reference

Osteoprotegerin deficiency and juvenile Paget's disease.

31 March 2020

1 reference

Osteoprotegerin deficiency and juvenile Paget's disease

31 March 2020

1 reference

A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype

31 March 2020

1 reference

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

31 March 2020

1 reference

Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease

31 March 2020

1 reference

Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling

31 March 2020

1 reference

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

31 March 2020

1 reference

Regulation of the immune response by SHIP.

31 March 2020

1 reference

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

31 March 2020

1 reference

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

31 March 2020

1 reference

Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release

31 March 2020

1 reference

Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells

31 March 2020

1 reference

Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy.

31 March 2020

1 reference

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency

31 March 2020

1 reference

Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo

31 March 2020

1 reference

Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production

31 March 2020

1 reference

M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss.

31 March 2020

1 reference

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha

31 March 2020

1 reference

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

31 March 2020

1 reference

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

31 March 2020

1 reference

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

31 March 2020

1 reference

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

31 March 2020

1 reference

Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal

31 March 2020

1 reference

Increased osteoclast development after estrogen loss: mediation by interleukin-6

31 March 2020

1 reference

Osteoclasts are present in gp130-deficient mice

31 March 2020

1 reference

Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease

31 March 2020

1 reference

Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

31 March 2020

1 reference

Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation

31 March 2020

1 reference

IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro

31 March 2020

1 reference

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

31 March 2020

1 reference

Interleukin 7 and estrogen-induced bone loss

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12897775

31 March 2020

Identifiers

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6 November 2019

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Consolidated OpenCitations Corpus – April 2017

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