Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (Q29617845)

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scientific article (publication date: November 2003)

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English	Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress	scientific article (publication date: November 2003)

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress (English)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14585973

30 April 2017

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (English)

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10.1128/MCB.23.22.8137-8151.2003

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protein ubiquitination

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inferred from title

signal transducing adaptor protein

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cytoskeletal proteins

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Donna D. Zhang

1

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Mark Hannink

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https://europepmc.org/articles/PMC262403

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https://europepmc.org/articles/PMC262403?pdf=render

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https://doi.org/10.1128/mcb.23.22.8137-8151.2003

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Molecular and Cellular Biology

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23

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8137-51

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30 April 2017

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

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A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation

1 reference

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30 April 2017

Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262403

30 April 2017

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

1 reference

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Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

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30 April 2017

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

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30 April 2017

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Manipulation of oxidative protein folding and PDI redox state in mammalian cells

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Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme

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30 April 2017

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

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30 April 2017

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

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30 April 2017

Mechanisms underlying ubiquitination

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30 April 2017

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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30 April 2017

Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins

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30 April 2017

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262403

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The kelch repeat superfamily of proteins: propellers of cell function

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30 April 2017

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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30 April 2017

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

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30 April 2017

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

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3 June 2018

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

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3 June 2018

Antioxidants and oxidants regulated signal transduction pathways

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3 June 2018

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

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Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

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Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

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Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism

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Inhibition of carcinogenesis by dietary polyphenolic compounds

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3 June 2018

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

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3 June 2018

Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism

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3 June 2018

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

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Progress in cancer chemoprevention: development of diet-derived chemopreventive agents

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Functional antioxidant responsive elements.

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Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

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Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

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Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells

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Nrf2-deficient female mice develop lupus-like autoimmune nephritis

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The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

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Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

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Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

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Journal of Biological Chemistry

13

77

2769

author name string

Huang H. C.

publication date

2002

1 reference

10.1128/MCB.23.22.8137-8151.2003

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Cancer Research

24

61

3299

author name string

McMahon M.

publication date

2001

1 reference

10.1128/MCB.23.22.8137-8151.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8137-8151.2003

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Cancer Research

39

62

5196

author name string

Thimmulappa R. K.

publication date

2002

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10.1128/MCB.23.22.8137-8151.2003

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26 March 2024

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10.1128/MCB.23.22.8137-8151.2003

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Consolidated OpenCitations Corpus – April 2017

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