Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (Q29622818)

Europe PubMed Central

title

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (English)

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30 April 2017

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Ferrara N

1

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30 April 2017

Hillan KJ

series ordinal

2

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Gerber HP

series ordinal

3

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Novotny W

series ordinal

4

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30 April 2017

language of work or name

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30 April 2017

publication date

May 2004

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Nature Reviews Drug Discovery

30 April 2017

published in

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volume

3

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page(s)

391-400

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issue

5

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VEGF and the quest for tumour angiogenesis factors

30 April 2017

cites work

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Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

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Vascular endothelial growth factor B, a novel growth factor for endothelial cells

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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

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Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family

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Molecular regulation of vessel maturation

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The biology of VEGF and its receptors

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Lymphangiogenesis and cancer metastasis

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

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Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

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Vascular endothelial growth factor is a secreted angiogenic mitogen

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Vascular permeability factor, an endothelial cell mitogen related to PDGF

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The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.

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The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

31 March 2020

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Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

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Vascular endothelial growth factor: basic science and clinical progress

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The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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The biology of vascular endothelial growth factor

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Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

31 March 2020

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Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy

31 March 2020

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During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium

31 March 2020

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Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene

31 March 2020

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Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

31 March 2020

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Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

31 March 2020

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Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

31 March 2020

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Blood vessels and nerves: common signals, pathways and diseases

31 March 2020

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

31 March 2020

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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

31 March 2020

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

31 March 2020

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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

31 March 2020

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

31 March 2020

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

31 March 2020

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Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment

31 March 2020

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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

31 March 2020

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Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

31 March 2020

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MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

31 March 2020

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Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

31 March 2020

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Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders

31 March 2020

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

31 March 2020

1 reference

HIF hydroxylation and the mammalian oxygen-sensing pathway

31 March 2020

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Angiogenesis in ischemic and neoplastic disorders

31 March 2020

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Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

31 March 2020

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von Hippel-Lindau disease

31 March 2020

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

31 March 2020

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

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Regulation of angiogenesis by hypoxia: role of the HIF system

31 March 2020

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Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells

31 March 2020

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Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

31 March 2020

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Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor (VEGF).

31 March 2020

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Host cyclooxygenase-2 modulates carcinoma growth.

31 March 2020

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Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

31 March 2020

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

31 March 2020

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

31 March 2020

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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

31 March 2020

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

31 March 2020

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Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody

31 March 2020

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Vascular endothelial growth factor is expressed in rat corpus luteum

31 March 2020

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Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary

31 March 2020

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Vascular endothelial growth factor is essential for corpus luteum angiogenesis.

31 March 2020

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Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor

31 March 2020

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Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys

31 March 2020

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Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer

31 March 2020

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Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma.

31 March 2020

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Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma

31 March 2020

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

31 March 2020

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Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

31 March 2020

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

31 March 2020

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Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis

31 March 2020

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Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo

31 March 2020

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

31 March 2020

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Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer

31 March 2020

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VEGF-Trap: a VEGF blocker with potent antitumor effects

31 March 2020

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Tumor induction of VEGF promoter activity in stromal cells

31 March 2020

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VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis

31 March 2020

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Tumorigenesis and the angiogenic switch

31 March 2020

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Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

31 March 2020

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Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

31 March 2020

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Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor

31 March 2020

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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

31 March 2020

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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface

31 March 2020

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Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

31 March 2020

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Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma

31 March 2020

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Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data

31 March 2020

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Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer

31 March 2020

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A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer

31 March 2020

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A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

31 March 2020

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Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer

31 March 2020

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Irinotecan plus fluorouracil/leucovorin for metastatic colorectal cancer: a new survival standard.

31 March 2020

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

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Angiogenesis inhibitors suffer new setback

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31 March 2020

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

31 March 2020

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2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

31 March 2020

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Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

31 March 2020

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A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.

31 March 2020

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Prognostic value of residual node involvement in operable breast cancer after induction chemotherapy

31 March 2020

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Clinical translation of angiogenesis inhibitors

31 March 2020

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

31 March 2020

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Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer a

31 March 2020

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The role of VEGF in normal and neoplastic hematopoiesis

31 March 2020

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15136787

31 March 2020

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405868

1006489607

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30 April 2017

Consolidated OpenCitations Corpus – April 2017