TGF-beta activated kinase 1 Dmel_CG18492 (Q29809612)

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Protein found in Drosophila melanogaster

CG18492-PA
transforming growth factor-beta activated kinase 1
Tak1-PB
TGF-beta activated-kinase 1
TGFbeta-activated kinase 1
transforming growth factor beta-activated kinase
CG18492 gene product from transcript CG18492-RA
transforming growth factor-beta-activated kinase 1
Tak1-PA
Tak1
TGF-beta activated kinase 1
TGF beta-activated kinase 1
CG18492-PB

Language	Label	Description	Also known as
English	TGF-beta activated kinase 1 Dmel_CG18492	Protein found in Drosophila melanogaster	CG18492-PA transforming growth factor-beta activated kinase 1 Tak1-PB TGF-beta activated-kinase 1 TGFbeta-activated kinase 1 transforming growth factor beta-activated kinase CG18492 gene product from transcript CG18492-RA transforming growth factor-beta-activated kinase 1 Tak1-PA Tak1 TGF-beta activated kinase 1 TGF beta-activated kinase 1 CG18492-PB

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9V3Q6

mitogen-activated protein (MAP) kinase kinase kinase 7

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9V3Q6

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

magnesium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

JUN kinase kinase kinase activity

determination method

1 reference

8 April 2019

Immune Activation of NF-κB and JNK Requires Drosophila TAK1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

MAP kinase kinase kinase activity

determination method

4 references

8 April 2019

Drosophila: the genetics of innate immune recognition and response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

8 April 2019

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

protein binding

determination method

1 reference

8 April 2019

TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

biological process

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

apoptotic process

determination method

1 reference

8 April 2019

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

positive regulation of antibacterial peptide biosynthetic process

determination method

1 reference

8 April 2019

Drosophila: the genetics of innate immune recognition and response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

determination method

1 reference

8 April 2019

Iap2 is required for a sustained response in the Drosophila Imd pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Immune Activation of NF-κB and JNK Requires Drosophila TAK1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

determination method

1 reference

8 April 2019

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

regulation of autophagy

determination method

1 reference

8 April 2019

TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

ommatidial rotation

determination method

1 reference

8 April 2019

The role of the Drosophila TAK homologue dTAK during development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

compound eye development

determination method

1 reference

8 April 2019

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

notum morphogenesis

determination method

1 reference

8 April 2019

The role of the Drosophila TAK homologue dTAK during development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

defense response to Gram-negative bacterium

determination method

3 references

8 April 2019

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

8 April 2019

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

8 April 2019

Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

defense response to virus

determination method

1 reference

8 April 2019

The Imd pathway is involved in antiviral immune responses in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

peptidoglycan recognition protein signaling pathway

determination method

1 reference

8 April 2019

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

cellular response to lipopolysaccharide

determination method

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

immune response

determination method

1 reference

8 April 2019

Immune Activation of NF-κB and JNK Requires Drosophila TAK1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V3Q6

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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