Retinoblastoma-family protein Dmel_CG7413 (Q29812151)

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Protein found in Drosophila melanogaster

Retinoblastoma-family protein
retinoblastoma factor
Rb
CG7413 gene product from transcript CG7413-RA
Rbf
retinoblastoma-family homolog
retinoblastoma factor-1
retinoblastoma family protein 1
Rbf-PA
CG7413-PA
retinoblastoma

Language	Label	Description	Also known as
English	Retinoblastoma-family protein Dmel_CG7413	Protein found in Drosophila melanogaster	Retinoblastoma-family protein retinoblastoma factor Rb CG7413 gene product from transcript CG7413-RA Rbf retinoblastoma-family homolog retinoblastoma factor-1 retinoblastoma family protein 1 Rbf-PA CG7413-PA retinoblastoma

Statements

1 reference

25 May 2022

UniProt protein ID

retinoblastoma protein family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24472

Cyclin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24472

Cyclin-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, B-box family

1 reference

based on heuristic

inferred from protein domain or family

Retinoblastoma-associated protein, A-box family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

protein binding

determination method

6 references

8 April 2019

Functional antagonism between E2F family members

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Drosophila cyclin E interacts with components of the Brahma complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

determination method

1 reference

27 March 2018

Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

determination method

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

27 March 2018

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

27 March 2018

A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

determination method

3 references

8 April 2019

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

biological process

negative regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24472&geneProductId=UniProtKB:Q24472

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

endomitotic cell cycle

determination method

1 reference

8 April 2019

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

negative regulation of DNA replication

determination method

1 reference

8 April 2019

DNA replication control through interaction of E2F-RB and the origin recognition complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of cell size

determination method

1 reference

8 April 2019

Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

1 reference

8 April 2019

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of cell death

determination method

1 reference

8 April 2019

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

maintenance of mitotic sister chromatid cohesion

determination method

1 reference

8 April 2019

Loss of pRB causes centromere dysfunction and chromosomal instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

DNA endoreduplication

determination method

1 reference

8 April 2019

The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

response to starvation

determination method

1 reference

8 April 2019

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Regulation of apoptosis of rbf mutant cells during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of DNA binding

determination method

1 reference

8 April 2019

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of chromosome segregation

determination method

1 reference

8 April 2019

Loss of pRB causes centromere dysfunction and chromosomal instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of cohesin loading

determination method

1 reference

8 April 2019

Loss of pRB causes centromere dysfunction and chromosomal instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of execution phase of apoptosis

determination method

1 reference

8 April 2019

dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

cell differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

negative regulation of G1/S transition of mitotic cell cycle

determination method

3 references

8 April 2019

Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24472

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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