Spastin Dmel_CG5977 (Q29812472)

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Protein found in Drosophila melanogaster

CG5977-PE
spas-PC
spas-PB
D-spastin
CG5977 gene product from transcript CG5977-RD
spasin
CG5977-PF
spas-PA
CG5977-PA
spas-PE
Dm-Spastin
dspastin
spas
CG5977-PC
CG5977-PB
spas-PF
CG5977-PD
spas-PD
spastin

Language	Label	Description	Also known as
English	Spastin Dmel_CG5977	Protein found in Drosophila melanogaster	CG5977-PE spas-PC spas-PB D-spastin CG5977 gene product from transcript CG5977-RD spasin CG5977-PF spas-PA CG5977-PA spas-PE Dm-Spastin dspastin spas CG5977-PC CG5977-PB spas-PF CG5977-PD spas-PD spastin

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8I0P1

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8I0P1

ATPase, AAA-type, core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MIT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

ATPase, AAA-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule binding

determination method or standard

1 reference

1 January 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule-severing ATPase activity

determination method or standard

4 references

16 July 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

16 July 2018

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

hydrolase activity

determination method or standard

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

ATPase activity

determination method or standard

1 reference

16 July 2018

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

alpha-tubulin binding

determination method or standard

1 reference

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule-severing ATPase activity

determination method or standard

5 references

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

isomerase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

microtubule organizing center

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

synaptic vesicle

determination method or standard

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule cytoskeleton

determination method or standard

1 reference

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

neuromuscular junction

determination method or standard

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

terminal bouton

determination method or standard

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

biological process

mitotic sister chromatid segregation

determination method or standard

1 reference

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule cytoskeleton organization

determination method or standard

3 references

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

multicellular organism development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

nervous system development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

locomotory behavior

determination method or standard

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

transmission of nerve impulse

determination method or standard

1 reference

8 April 2019

The centrosome in human genetic disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

cell differentiation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of microtubule depolymerization

determination method or standard

4 references

1 January 2018

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

1 January 2018

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

1 January 2018

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

1 January 2018

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8I0P1&geneProductId=UniProtKB:Q8I0P1

determination method or standard

hemocyte migration

determination method or standard

1 reference

8 April 2019

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of lipid metabolic process

determination method or standard

1 reference

8 April 2019

Spastin binds to lipid droplets and affects lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

negative regulation of synaptic assembly at neuromuscular junction

determination method or standard

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of synaptic assembly at neuromuscular junction

determination method or standard

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

regulation of synaptic plasticity

determination method or standard

1 reference

8 April 2019

The centrosome in human genetic disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of axon extension involved in regeneration

determination method or standard

1 reference

8 April 2019

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of dendrite morphogenesis

determination method or standard

1 reference

8 April 2019

Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule severing

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

negative regulation of neuromuscular synaptic transmission

determination method or standard

1 reference

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of neuromuscular synaptic transmission

determination method or standard

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

regulation of terminal button organization

determination method or standard

1 reference

8 April 2019

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

mitotic spindle elongation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

mitotic chromosome movement towards spindle pole

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

adult locomotory behavior

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

positive regulation of microtubule depolymerization

determination method or standard

5 references

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

protein hexamerization

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

regulation of synapse structure or activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

microtubule severing

determination method or standard

3 references

8 April 2019

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

cytoplasmic microtubule organization

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8I0P1

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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