P38a MAP kinase Dmel_CG5475 (Q29812511)

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Protein found in Drosophila melanogaster

p38a
CG5475 gene product from transcript CG5475-RB
p38a-PB
Erk-kinase-like
p38 mitogen-activated protein kinase
stress-activated kinase P38
CG5475-PC
p38 MAP kinase
p38a-PC
CG5475-PB
p38a-PA
CG5475-PA
p38a MAP kinase
Mpk2

Language	Label	Description	Also known as
English	P38a MAP kinase Dmel_CG5475	Protein found in Drosophila melanogaster	p38a CG5475 gene product from transcript CG5475-RB p38a-PB Erk-kinase-like p38 mitogen-activated protein kinase stress-activated kinase P38 CG5475-PC p38 MAP kinase p38a-PC CG5475-PB p38a-PA CG5475-PA p38a MAP kinase Mpk2

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O62618

mitogen-activated protein (MAP) kinase p38-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O62618

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

MAP kinase activity

determination method or standard

5 references

16 July 2018

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O62618&geneProductId=UniProtKB:O62618

determination method or standard

16 July 2018

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O62618&geneProductId=UniProtKB:O62618

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O62618&geneProductId=UniProtKB:O62618

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O62618&geneProductId=UniProtKB:O62618

determination method or standard

16 July 2018

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=O62618&geneProductId=UniProtKB:O62618

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

MAP kinase activity

determination method or standard

6 references

8 April 2019

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

biological process

determination method or standard

3 references

8 April 2019

p38 MAPK signalling cascades: ancient roles and new functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

mucosal immune response

determination method or standard

1 reference

8 April 2019

Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

heart morphogenesis

determination method or standard

1 reference

8 April 2019

ROS regulate cardiac function via a distinct paracrine mechanism.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

response to oxidative stress

determination method or standard

1 reference

8 April 2019

An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

determination of adult lifespan

determination method or standard

1 reference

8 April 2019

A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

negative regulation of antimicrobial humoral response

determination method or standard

1 reference

8 April 2019

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

response to heat

determination method or standard

3 references

8 April 2019

An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

regulation of gene expression

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

cellular response to reactive oxygen species

determination method or standard

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

paracrine signaling

determination method or standard

1 reference

8 April 2019

ROS regulate cardiac function via a distinct paracrine mechanism.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

response to hydrogen peroxide

determination method or standard

1 reference

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

positive regulation of cell size

determination method or standard

1 reference

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

regulation of adult chitin-containing cuticle pigmentation

determination method or standard

1 reference

8 April 2019

p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

defense response to fungus

determination method or standard

1 reference

8 April 2019

Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

cellular response to arsenic-containing substance

determination method or standard

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

cellular response to cadmium ion

determination method or standard

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

ROS regulate cardiac function via a distinct paracrine mechanism.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

regulation of cellular response to oxidative stress

determination method or standard

1 reference

8 April 2019

A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

cellular response to organic substance

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62618

determination method or standard

mitogen-activated protein (MAP) kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O62618

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O62618

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O62618

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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