Suppressor of Hairless Dmel_CG3497 (Q29813727)

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Protein found in Drosophila melanogaster
  • transcription unit C
  • lethal group D
  • CG3497 gene product from transcript CG3497-RA
  • lethal 7 in the black-reduced region
  • CG3497-PC
  • suppressor-of-hairless
  • Su(H)
  • suppressor of hairless
  • CG3497-PA
  • Su(H)-PA
  • Su(H)-PC
  • supressor of hairless
edit
Language Label Description Also known as
English
Suppressor of Hairless Dmel_CG3497
Protein found in Drosophila melanogaster
  • transcription unit C
  • lethal group D
  • CG3497 gene product from transcript CG3497-RA
  • lethal 7 in the black-reduced region
  • CG3497-PC
  • suppressor-of-hairless
  • Su(H)
  • suppressor of hairless
  • CG3497-PA
  • Su(H)-PA
  • Su(H)-PC
  • supressor of hairless

Statements

molecular function
DNA binding
determination method
IDA
IEA
NAS
TAS
6 references
retrieved
1 January 2018
stated in
strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
TAS
retrieved
1 January 2018
stated in
Asymmetric localization and function of cell-fate determinants: a fly's view
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
NAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IEA
retrieved
1 January 2018
stated in
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
1 January 2018
stated in
Dissecting the mechanisms of Notch induced hyperplasia
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IDA
protein binding
determination method
IPI
9 references
retrieved
8 April 2019
stated in
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
The suppressor of hairless protein participates in notch receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
retrieved
8 April 2019
stated in
The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IPI
DNA-binding transcription activator activity, RNA polymerase II-specific
determination method
IBA
IDA
IMP
6 references
retrieved
10 September 2018
stated in
An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
10 September 2018
stated in
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IBA
retrieved
7 November 2018
stated in
An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
7 November 2018
stated in
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
7 November 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IBA
RNA polymerase II transcription regulatory region sequence-specific DNA binding
determination method
IDA
IMP
6 references
retrieved
8 April 2019
stated in
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
8 April 2019
stated in
An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
8 April 2019
stated in
Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
8 April 2019
stated in
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
8 April 2019
stated in
The bHLH-PAS transcription factor dysfusion regulates tarsal joint formation in response to Notch activity during drosophila leg development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
8 April 2019
stated in
Dissecting the mechanisms of Notch induced hyperplasia
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
cell component
biological process
Notch signaling pathway
determination method
IEA
IGI
IMP
NAS
TAS
7 references
retrieved
1 January 2018
stated in
Cell fate specification in the Drosophila retina
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
TAS
retrieved
1 January 2018
stated in
strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
TAS
retrieved
1 January 2018
stated in
Runt and Lozenge function in Drosophila development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
NAS
retrieved
1 January 2018
stated in
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
1 January 2018
stated in
Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
1 January 2018
stated in
The suppressor of hairless protein participates in notch receptor signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IGI
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IEA
Notch signaling pathway
determination method
IDA
IEA
IGI
IMP
NAS
TAS
10 references
retrieved
14 January 2019
stated in
Cell fate specification in the Drosophila retina
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
TAS
retrieved
14 January 2019
stated in
Runt and Lozenge function in Drosophila development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
NAS
retrieved
14 January 2019
stated in
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
14 January 2019
stated in
The bHLH-PAS transcription factor dysfusion regulates tarsal joint formation in response to Notch activity during drosophila leg development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
14 January 2019
stated in
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
14 January 2019
stated in
Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
14 January 2019
stated in
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IGI
retrieved
14 January 2019
stated in
The suppressor of hairless protein participates in notch receptor signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IGI
retrieved
14 January 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IEA
retrieved
14 January 2019
stated in
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28159&geneProductId=UniProtKB:P28159
determination method
IDA
Notch signaling pathway
determination method
IDA
IEA
IGI
IMP
9 references
retrieved
8 April 2019
stated in
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
8 April 2019
stated in
Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
8 April 2019
stated in
The bHLH-PAS transcription factor dysfusion regulates tarsal joint formation in response to Notch activity during drosophila leg development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
8 April 2019
stated in
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IMP
retrieved
8 April 2019
stated in
The suppressor of hairless protein participates in notch receptor signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IGI
retrieved
8 April 2019
stated in
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28159
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IEA
retrieved
8 April 2019
stated in
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA
retrieved
8 April 2019
stated in
Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28159
determination method
IDA

Identifiers

 
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