Slipper Dmel_CG2272 (Q29814484)

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Protein found in Drosophila melanogaster

slpr-PB
slpr-PD
slpr-PA
CG2272-PC
CG2272 gene product from transcript CG2272-RC
slpr
CG2272-PD
slpr-PC
mixed lineage protein kinase 2
slipper
CG2272-PA
CG2272-PB

Language	Label	Description	Also known as
English	Slipper Dmel_CG2272	Protein found in Drosophila melanogaster	slpr-PB slpr-PD slpr-PA CG2272-PC CG2272 gene product from transcript CG2272-RC slpr CG2272-PD slpr-PC mixed lineage protein kinase 2 slipper CG2272-PA CG2272-PB

Statements

1 reference

25 May 2022

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q95UN8

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q95UN8

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

protein kinase activity

determination method

3 references

8 April 2019

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

protein serine/threonine kinase activity

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q95UN8&geneProductId=UniProtKB:Q95UN8

determination method

JUN kinase kinase kinase activity

determination method

4 references

16 July 2018

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q95UN8&geneProductId=UniProtKB:Q95UN8

determination method

16 July 2018

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q95UN8&geneProductId=UniProtKB:Q95UN8

determination method

16 July 2018

Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q95UN8&geneProductId=UniProtKB:Q95UN8

determination method

16 July 2018

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q95UN8&geneProductId=UniProtKB:Q95UN8

determination method

MAP kinase kinase kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

JUN kinase kinase kinase activity

determination method

5 references

8 April 2019

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

determination method

1 reference

8 April 2019

Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

biological process

protein phosphorylation

determination method

4 references

8 April 2019

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

determination method

4 references

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

determination method

5 references

8 April 2019

Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Epithelial fusions in the embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

dorsal closure, elongation of leading edge cells

determination method

1 reference

8 April 2019

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

response to heat

determination method

1 reference

8 April 2019

Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

positive regulation of JNK cascade

determination method

2 references

imaginal disc fusion, thorax closure

determination method

dorsal appendage formation

determination method

1 reference

8 April 2019

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

imaginal disc-derived male genitalia morphogenesis

determination method

1 reference

8 April 2019

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

imaginal disc-derived female genitalia morphogenesis

determination method

1 reference

8 April 2019

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

cellular response to ethanol

determination method

1 reference

8 April 2019

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

imaginal disc fusion, thorax closure

determination method

3 references

8 April 2019

The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

8 April 2019

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

vascular endothelial growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q95UN8

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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