Spitz Dmel_CG10334 (Q29816356)

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Protein found in Drosophila melanogaster

CG10334-PE
spi
CG10334-PG
spi-PG
spitz
CG10334 gene product from transcript CG10334-RF
spi-PA
spi-PE
CG10334-PF
CG10334-PA
spi-PF
spi-PB
epidermal growth factor protein
CG10334-PB

Language	Label	Description	Also known as
English	Spitz Dmel_CG10334	Protein found in Drosophila melanogaster	CG10334-PE spi CG10334-PG spi-PG spitz CG10334 gene product from transcript CG10334-RF spi-PA spi-PE CG10334-PF CG10334-PA spi-PF spi-PB epidermal growth factor protein CG10334-PB

Statements

1 reference

25 May 2022

UniProt protein ID

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

epidermal growth factor receptor binding

determination method

3 references

1 January 2018

Localized activation of RTK/MAPK pathways during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Signaling by the Drosophila epidermal growth factor receptor pathway during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

protein binding

determination method

3 references

8 April 2019

Structural basis for EGFR ligand sequestration by Argos

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

epidermal growth factor receptor binding

determination method

4 references

8 April 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

receptor ligand activity

determination method

5 references

8 April 2019

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

endoplasmic reticulum

determination method

4 references

1 January 2018

Signaling by the Drosophila epidermal growth factor receptor pathway during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

integral component of membrane

determination method

3 references

1 January 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Signaling by the Drosophila epidermal growth factor receptor pathway during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

extracellular space

determination method

4 references

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

biological process

G2/M transition of mitotic cell cycle

determination method

1 reference

1 January 2018

Cell proliferation, survival, and death in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

determination method

1 reference

8 April 2019

Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

epidermal growth factor receptor signaling pathway

determination method

4 references

1 January 2018

Localized activation of RTK/MAPK pathways during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Signaling by the Drosophila epidermal growth factor receptor pathway during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Generating patterns from fields of cells. Examples from Drosophila segmentation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

1 January 2018

Epidermal growth factor receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

border follicle cell migration

determination method

1 reference

16 July 2018

Multiple EGFR ligands participate in guiding migrating border cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

determination method

1 reference

8 April 2019

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

nervous system development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

stomatogastric nervous system development

determination method

1 reference

8 April 2019

Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

peripheral nervous system development

determination method

1 reference

8 April 2019

Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

open tracheal system development

determination method

1 reference

1 January 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

salivary gland boundary specification

determination method

1 reference

1 January 2018

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

8 April 2019

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

olfactory learning

determination method

1 reference

8 April 2019

EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

second mitotic wave involved in compound eye morphogenesis

determination method

1 reference

1 January 2018

Cell proliferation, survival, and death in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

determination of genital disc primordium

determination method

1 reference

8 April 2019

Allocation and specification of the genital disc precursor cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

spiracle morphogenesis, open tracheal system

determination method

1 reference

8 April 2019

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

R8 cell-mediated photoreceptor organization

determination method

1 reference

1 January 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

positive regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

1 January 2018

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

negative regulation of compound eye retinal cell programmed cell death

determination method

1 reference

1 January 2018

Patterning the fly eye: the role of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

branched duct epithelial cell fate determination, open tracheal system

determination method

1 reference

1 January 2018

Cell fate choices in Drosophila tracheal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083

determination method

behavioral response to ethanol

determination method

1 reference

8 April 2019

Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

stem cell fate commitment

determination method

1 reference

8 April 2019

Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

positive regulation of neurogenesis

determination method

1 reference

8 April 2019

Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

epithelial cell proliferation involved in Malpighian tubule morphogenesis

determination method

1 reference

8 April 2019

Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

ectodermal cell fate determination

determination method

1 reference

8 April 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

epidermal growth factor receptor signaling pathway

determination method

11 references

8 April 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

8 April 2019

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

ommatidial rotation

determination method

1 reference

8 April 2019

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Control of compartment size by an EGF ligand from neighboring cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

photoreceptor cell fate determination

determination method

1 reference

8 April 2019

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

photoreceptor cell differentiation

determination method

1 reference

8 April 2019

Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

positive regulation of border follicle cell migration

determination method

1 reference

8 April 2019

Multiple EGFR ligands participate in guiding migrating border cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083

determination method

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01083

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01083

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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