Adenomatous polyposis coli 2 Dmel_CG6193 (Q29817349)

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protein found in Drosophila melanogaster
  • Apc2-PC
  • CG6193-PA
  • Apc2
  • adenomatous polyposis coli tumor suppressor homolog 2
  • adenomatous polyposis coli 2
  • Apc2-PB
  • CG6193-PB
  • CG6193 gene product from transcript CG6193-RC
  • CG6193-PC
  • epithelial adenomatous polyposis coli
  • Apc2-PA
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Language Label Description Also known as
English
Adenomatous polyposis coli 2 Dmel_CG6193
protein found in Drosophila melanogaster
  • Apc2-PC
  • CG6193-PA
  • Apc2
  • adenomatous polyposis coli tumor suppressor homolog 2
  • adenomatous polyposis coli 2
  • Apc2-PB
  • CG6193-PB
  • CG6193 gene product from transcript CG6193-RC
  • CG6193-PC
  • epithelial adenomatous polyposis coli
  • Apc2-PA

Statements

molecular function
cell component
biological process
negative regulation of canonical Wnt signaling pathway
determination method
IGI
IMP
10 references
retrieved
21 June 2018
stated in
The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
21 June 2018
stated in
Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
21 June 2018
stated in
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
21 June 2018
stated in
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
21 June 2018
stated in
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
21 June 2018
stated in
Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
21 June 2018
stated in
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
21 June 2018
stated in
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
21 June 2018
stated in
Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
21 June 2018
stated in
The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y1T2&geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
negative regulation of canonical Wnt signaling pathway
determination method
IBA
IGI
IMP
11 references
retrieved
8 April 2019
stated in
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
8 April 2019
stated in
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
8 April 2019
stated in
Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
8 April 2019
stated in
The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IGI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y1T2
determination method
IBA

Identifiers

 
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