Serrate Dmel_CG6127 (Q29817745)

Jagged/Serrate protein

1 reference

VWFC domain, protein family

1 reference

Notch ligand, N-terminal domain, protein family

1 reference

Delta/Serrate/lag-2 (DSL) protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

signaling receptor binding

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

1 January 2018

Signal dispersal and transduction through the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

5 references

1 January 2018

The polarisation of the anteroposterior axis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

Cell fate specification in the Drosophila retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

4 references

14 January 2019

Cell fate specification in the Drosophila retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

4 references

8 April 2019

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

8 April 2019

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

8 April 2019

In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

glycosphingolipid binding

IDA

1 reference

9 May 2019

Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

IDA

receptor ligand activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

5 references

9 May 2019

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

integral component of membrane

IDA

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

NAS

3 references

apical plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

Cell fate specification in the Drosophila retina

Notch signaling pathway

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

sensory organ development

1 reference

9 May 2019

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

salivary gland development

1 reference

1 January 2018

Constructing an organ: the Drosophila salivary gland as a model for tube formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

larval salivary gland morphogenesis

NAS

1 reference

9 May 2019

Specification of cell fates within the salivary gland primordium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

dorsal/ventral lineage restriction, imaginal disc

1 reference

1 January 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

imaginal disc-derived wing morphogenesis

TAS

1 reference

9 May 2019

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development

glial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

second mitotic wave involved in compound eye morphogenesis

1 reference

9 May 2019

A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

germ-line stem cell population maintenance

1 reference

9 May 2019

Stem cells signal to the niche through the Notch pathway in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

cuticle pattern formation

IGI

1 reference

9 May 2019

Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

larval lymph gland hemopoiesis

1 reference

9 May 2019

A Serrate-expressing signaling center controls Drosophila hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

lymph gland crystal cell differentiation

IEP

1 reference

16 July 2018

Blood cells of Drosophila: cell lineages and role in host defence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

negative regulation of lamellocyte differentiation

TAS

1 reference

9 May 2019

An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

eye-antennal disc development

1 reference

9 May 2019

Lobe and Serrate are required for cell survival during early eye development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

imaginal disc-derived leg segmentation

1 reference

9 May 2019

Notch-mediated segmentation and growth control of the Drosophila leg.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

crystal cell differentiation

3 references

1 January 2018

Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

A Serrate-expressing signaling center controls Drosophila hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 January 2018

Notch signaling controls lineage specification during Drosophila larval hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

regulation of crystal cell differentiation

1 reference

1 January 2018

Transcriptional regulation of hematopoiesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

negative regulation of Notch signaling pathway

TAS

1 reference

1 January 2018

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

1 reference

9 May 2019

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

Lobe and Serrate are required for cell survival during early eye development in Drosophila

compound eye development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

Notch signaling pathway

5 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18168&geneProductId=UniProtKB:P18168

salivary gland morphogenesis

1 reference

9 May 2019

Specification of cell fates within the salivary gland primordium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

imaginal disc-derived wing margin morphogenesis

1 reference

9 May 2019

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

Notch signaling pathway

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

wing disc anterior/posterior pattern formation

1 reference

9 May 2019

Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

negative regulation of Notch signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18168

EGF-like calcium-binding, conserved site

IBA

has part(s)

1 reference

Notch ligand, N-terminal domain

1 reference

EGF-like domain

1 reference

EGF-like, conserved site

1 reference

VWFC domain

1 reference

Delta/Serrate/lag-2 (DSL) protein

1 reference

EGF-like calcium-binding domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference