Reaper Dmel_CG4319 (Q29818445)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

1 reference

8 April 2019

Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

ubiquitin conjugating enzyme binding

1 reference

8 April 2019

Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

protein homodimerization activity

IPI

1 reference

8 April 2019

Drosophila IAP antagonists form multimeric complexes to promote cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

1 reference

8 April 2019

An emerging blueprint for apoptosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

1 reference

8 April 2019

A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

mitochondrial outer membrane

1 reference

8 April 2019

Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

11 references

8 April 2019

Apoptosis. The little devil of death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Activation of the reaper gene during ectopic cell killing in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Genetic control of programmed cell death in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

reaper is required for neuroblast apoptosis during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Drosophila IAP antagonists form multimeric complexes to promote cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Activation of the reaper gene during ectopic cell killing in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

1 reference

8 April 2019

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

intrinsic apoptotic signaling pathway in response to osmotic stress

1 reference

8 April 2019

Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

intrinsic apoptotic signaling pathway in response to DNA damage

TAS

1 reference

8 April 2019

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.

programmed cell death

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Death to flies: Drosophila as a model system to study programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

positive regulation of protein ubiquitination

1 reference

8 April 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

salivary gland cell autophagic cell death

1 reference

8 April 2019

A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

ecdysone-mediated induction of salivary gland cell autophagic cell death

1 reference

8 April 2019

A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

larval midgut cell programmed cell death

IEP

1 reference

8 April 2019

A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

larval central nervous system remodeling

1 reference

8 April 2019

Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

regulation of protein catabolic process

TAS

1 reference

8 April 2019

Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

negative regulation of neuron apoptotic process

1 reference

8 April 2019

Coordinated expression of cell death genes regulates neuroblast apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

imaginal disc-derived male genitalia morphogenesis

1 reference

8 April 2019

Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

cellular response to ionizing radiation

1 reference

8 April 2019

The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

cellular response to gamma radiation

1 reference

8 April 2019

Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

apoptotic signaling pathway

3 references

8 April 2019

Ras promotes cell survival in Drosophila by downregulating hid expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

Cell killing by the Drosophila gene reaper

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

8 April 2019

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

positive regulation of cysteine-type endopeptidase activity

1 reference

8 April 2019

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475

positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

1 reference

8 April 2019

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24475