Costa Dmel_CG1708 (Q29821017)

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Protein found in Drosophila melanogaster
  • cos-PA
  • Costal-2
  • CG1708 gene product from transcript CG1708-RA
  • CG1708-PB
  • Kinesin_B
  • costal 2
  • CG1708-PA
  • cos
  • DmCostal2
  • costa
  • cos-PB
  • enhancer of epaulette
  • costal2
edit
Language Label Description Also known as
English
Costa Dmel_CG1708
Protein found in Drosophila melanogaster
  • cos-PA
  • Costal-2
  • CG1708 gene product from transcript CG1708-RA
  • CG1708-PB
  • Kinesin_B
  • costal 2
  • CG1708-PA
  • cos
  • DmCostal2
  • costa
  • cos-PB
  • enhancer of epaulette
  • costal2

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
GOA
curator
UniProt
UniProt protein ID
O16844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
8 April 2019
stated in
A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844
determination method
IPI
cell component
biological process
negative regulation of smoothened signaling pathway
determination method
IMP
IPI
5 references
retrieved
7 November 2018
stated in
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844
determination method
IPI
retrieved
7 November 2018
stated in
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844
determination method
IMP
retrieved
7 November 2018
stated in
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844
determination method
IMP
retrieved
7 November 2018
stated in
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844
determination method
IMP
retrieved
7 November 2018
stated in
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844
determination method
IMP

Identifiers

 
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