Suppressor of fused Dmel_CG6054 (Q29821023)

Suppressor of fused, N-terminal

1 reference

Suppressor of fused, C-terminal domain superfamily

1 reference

Suppressor of fused-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Suppressor of fused C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

transcription corepressor activity

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

signal transducer activity

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

4 references

8 April 2019

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

A protein interaction map of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

transcription factor binding

IPI

3 references

8 April 2019

Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

Hedgehog signaling complex

cell component

1 reference

27 February 2018

Identification of a tetrameric hedgehog signaling complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

protein-containing complex

IPI

1 reference

8 April 2019

Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

multicellular organism development

IEA

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

negative regulation of protein binding

1 reference

8 April 2019

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

negative regulation of DNA-binding transcription factor activity

IMP

1 reference

27 February 2018

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

negative regulation of smoothened signaling pathway

IGI

1 reference

10 September 2018

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

negative regulation of nucleic acid-templated transcription

IGI

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VG38&geneProductId=UniProtKB:Q9VG38

cytoplasmic sequestering of transcription factor

IEA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

negative regulation of smoothened signaling pathway

6 references

8 April 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

8 April 2019

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VG38

negative regulation of nucleocytoplasmic transport

IDA

Suppressor of fused-like domain

1 reference

Suppressor of fused C-terminal

1 reference