The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation (Q30155858)

8 June 2017

The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation (English)

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8 June 2017

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Wing Chan

1

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8 June 2017

Soon-Tuck Sit

series ordinal

2

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8 June 2017

Ed Manser

series ordinal

3

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8 June 2017

language of work or name

English

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publication date

1 April 2011

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8 June 2017

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8 June 2017

435

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8 June 2017

2

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8 June 2017

355-364

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A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

8 June 2017

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https://api.crossref.org/works/10.1042%2FBJ20102156

ARK-1 inhibits EGFR signaling in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

The Cdc42 target ACK2 directly interacts with clathrin and influences clathrin assembly

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Dysregulation of Ack1 inhibits down-regulation of the EGF receptor

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

SAM domain-based protein oligomerization observed by live-cell fluorescence fluctuation spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Oligomeric structure of the human EphB2 receptor SAM domain

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Focal adhesion kinase regulation of N-WASP subcellular localization and function

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Ubiquitin-mediated degradation of active Src tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Autophosphorylation of Tyr397 and its phosphorylation by Src-family kinases are altered in focal-adhesion-kinase neuronal isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Src family kinases, key regulators of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

SH2- and SH3-mediated interactions between focal adhesion kinase and Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20102156

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Selected glimpses into the activation and function of Src kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20102156

21 January 2018

Identifiers

DOI

10.1042/BJ20102156

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8 June 2017

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