Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation (Q30304589)

12 October 2017

Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation (English)

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12 October 2017

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Suttitanamongkol S

1

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12 October 2017

Gear AR

series ordinal

2

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12 October 2017

Polanowska-Grabowska R

series ordinal

3

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12 October 2017

language of work or name

English

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publication date

1 January 2000

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12 October 2017

8

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inferred from page(s)

published in

Biochemical Journal

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12 October 2017

345 Pt 2

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12 October 2017

307-314

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The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

12 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Geldanamycin prevents nuclear translocation of mutant p53.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Platelet adhesion to collagen under flow causes dissociation of a phosphoprotein complex of heat-shock proteins and protein phosphatase 1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Platelet adhesion, shape change, and aggregation: rapid initiation and signal transduction events.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Myosin phosphorylation in intact platelets.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Secretory mechanisms. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Subsecond calcium dynamics in ADP- and thrombin-stimulated platelets: a continuous-flow approach using indo-1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Application of spray-freezing to the study of rapid platelet reactions by a quenched-flow approach

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Differential effects of chlorpromazine on secretion, protein phosphorylation and phosphoinositide metabolism in stimulated platelets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

The solubilization and morphological change of human platelets in various detergents

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Effect of herbimycin A on growth and pp60c-src activity in human colon tumor cell lines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Growth inhibition of virus transformed cells in vitro and antitumor activity in vivo of geldanamycin and its derivatives

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Herbimycin, a new antibiotic produced by a strain of Streptomyces

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Geldanamycin, a new antibiotic

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220760

Non-receptor protein tyrosine kinases and phosphatases in human platelets

26 November 2018

1 reference

12 December 2020

Phosphorylation and dephosphorylation mechanisms in platelet function: a tightly regulated balance

1 reference

12 December 2020

The Ah receptor is a sensitive target of geldanamycin-induced protein turnover

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12 December 2020

Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure

1 reference

12 December 2020

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

1 reference

12 December 2020

Adenine nucleotide metabolism of human platelets. Thin-layer chromatographic separation of labelled adenine nucleotides

1 reference

12 December 2020

Protein phosphorylation in platelets stimulated by immobilized thrombin at 37 degrees and 4 degrees C

1 reference

12 December 2020

Serotonin transport in isolated platelet granules. Coupling to the electrochemical proton gradient

1 reference

12 December 2020

Bioenergetics of serotonin transport by membrane vesicles derived from platelet dense granules

1 reference

12 December 2020

Thrombin-induced secretion of serotonin from platelets can occur in seconds

1 reference

12 December 2020

Rapid reactions of platelets studied by a quenched-flow approach: aggregation kinetics

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12 December 2020

Inhibition of DNA synthesis in murine tumor cells by geldanamycin, an antibiotic of the benzoquinoid ansamycin group

1 reference

12 December 2020

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1 reference

12 December 2020

Rapid platelet morphological changes visualized by scanning-electron microscopy: kinetics derived from a quenched-flow approach

1 reference

12 December 2020

10.1042/0264-6021:3450307

Identifiers

DOI

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12 October 2017

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12 October 2017

PubMed publication ID

10620508

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