Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations. (Q30333186)

14 October 2017

Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations. (English)

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14 October 2017

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3

Steven J Shire

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14 October 2017

James D Andya

1

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PMC publication ID

2751518

14 October 2017

Chung C Hsu

series ordinal

2

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14 October 2017

1 January 2003

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14 October 2017

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14 October 2017

5

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14 October 2017

2

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14 October 2017

E10

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A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751518

The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751518

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751518

Rational design of stable lyophilized protein formulations: some practical advice

3 June 2018

1 reference

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Humanization of an antibody directed against IgE

3 June 2018

1 reference

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Solid-phase aggregation of proteins under pharmaceutically relevant conditions

3 June 2018

1 reference

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Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751518

Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation

3 June 2018

1 reference

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New insight into protein secondary structure from resolution-enhanced infrared spectra

3 June 2018

1 reference

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Stability of protein pharmaceuticals

3 June 2018

1 reference

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Dominant forces in protein folding

3 June 2018

1 reference

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Determining the optimum residual moisture in lyophilized protein pharmaceuticals

3 June 2018

1 reference

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Humanization of an anti-p185HER2 antibody for human cancer therapy

3 June 2018

1 reference

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Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid)—a reexamination

3 June 2018

1 reference

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Determining the water sorption monolayer of lyophilized pharmaceutical proteins.

3 June 2018

1 reference

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Feasibility study on spray-drying protein pharmaceuticals: recombinant human growth hormone and tissue-type plasminogen activator.

26 November 2018

1 reference

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An infrared spectroscopic study of the interactions of carbohydrates with dried proteins

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751518

On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

26 November 2018

1 reference

12 December 2020

Protein secondary structures in water from second-derivative amide I infrared spectra

1 reference

12 December 2020

An infrared and circular dichroism combined approach to the analysis of protein secondary structure

1 reference

12 December 2020

Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation

1 reference

12 December 2020

Identifiers

DOI

10.1208/PS050210

1 reference

14 October 2017

1 reference

PMC publication ID

2751518

14 October 2017

PubMed publication ID

12866937

1 reference

PMC publication ID

2751518