Charting biologically relevant chemical space: a structural classification of natural products (SCONP) (Q30351855)

16 September 2017

Charting biologically relevant chemical space: a structural classification of natural products (SCONP) (English)

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natural product chemistry

16 September 2017

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7

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16 September 2017

8

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16 September 2017

2

Ansgar Schuffenhauer

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16 September 2017

Marcus A Koch

1

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16 September 2017

Michael Scheck

3

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16 September 2017

Stefan Wetzel

4

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16 September 2017

Marco Casaulta

5

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16 September 2017

Alex Odermatt

6

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16 September 2017

language of work or name

English

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publication date

21 November 2005

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16 September 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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16 September 2017

102

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16 September 2017

48

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16 September 2017

17272-17277

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Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

What can a chemist learn from nature's macrocycles?--a brief, conceptual view.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Lessons from natural molecules

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Compound library development guided by protein structure similarity clustering and natural product structure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Successful herbivore attack due to metabolic diversion of a plant chemical defense

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Protein structure similarity as guiding principle for combinatorial library design.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

A specific mechanism of nonspecific inhibition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Why do we need so many chemical similarity search methods?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Constraints on effectiveness of cyanogenic glycosides in herbivore defense

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Glycosides in medicine: "The role of glycosidic residue in biological activity".

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

The properties of known drugs. 1. Molecular frameworks

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297657

A new method to detect related function among proteins independent of sequence and fold homology.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0503647102

Enhancing the Effectiveness of Virtual Screening by Fusing Nearest Neighbor Lists: A Comparison of Similarity Coefficients

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16301544

12 December 2020

inferred from PubMed ID database lookup

Chemical space and biology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16301544

12 December 2020

inferred from PubMed ID database lookup

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16301544

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0503647102

1 reference

16 September 2017

0 references

1 reference

16 September 2017

PubMed publication ID

16301544

1 reference