Removing T-cell epitopes with computational protein design. (Q30362724)

23 September 2017

Removing T-cell epitopes with computational protein design. (English)

1 reference

23 September 2017

0 references

computational biology

1 reference

David Baker

7

0 references

Ira Pastan

5

object named as

Ira Pastan

1 reference

23 September 2017

Chris King

1

1 reference

23 September 2017

Esteban N Garza

2

1 reference

23 September 2017

Ronit Mazor

3

1 reference

23 September 2017

Jonathan L Linehan

4

1 reference

23 September 2017

Marion Pepper

6

1 reference

23 September 2017

language of work or name

English

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publication date

19 May 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

23 September 2017

1 reference

23 September 2017

111

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23 September 2017

23

1 reference

23 September 2017

8577-8582

1 reference

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

23 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Structure-based redesign of proteins for minimal T-cell epitope content

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Large-scale characterization of peptide-MHC binding landscapes with structural simulations.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

NetMHCIIpan-2.0 - Improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Pre-clinical considerations in the assessment of immunogenicity for protein therapeutics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

MHC class II epitope predictive algorithms.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Optimization algorithms for functional deimmunization of therapeutic proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

The immune epitope database 2.0.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Engineering and characterization of a superfolder green fluorescent protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

A beta-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Recombinant immunotoxins in the treatment of cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Naive and memory B cells in T-cell-dependent and T-independent responses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Several common HLA-DR types share largely overlapping peptide binding repertoires

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060723

Rationally engineered therapeutic proteins with reduced immunogenicity.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321126111

Optimization of therapeutic proteins to delete T-cell epitopes while maintaining beneficial residue interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321126111

Automating human intuition for protein design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321126111

ProPred: prediction of HLA-DR binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321126111

Optimizing techniques for tracking transplanted stem cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1321126111

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24843166

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24843166

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1321126111

1 reference

journals/pnas/KingGMLPPB14

23 September 2017

0 references

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

23 September 2017

PubMed publication ID

24843166

1 reference