Allosteric regulation and catalysis emerge via a common route. (Q30370820)

21 June 2017

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title

Allosteric regulation and catalysis emerge via a common route. (English)

1 reference

21 June 2017

Nina M Goodey

1

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PubMed ID

18641628

21 June 2017

Stephen J Benkovic

series ordinal

2

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21 June 2017

1 August 2008

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21 June 2017

Nature Chemical Biology

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21 June 2017

4

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21 June 2017

8

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21 June 2017

474-482

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

21 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The origin of protein interactions and allostery in colocalization

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The dynamic energy landscape of dihydrofolate reductase catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Characterization of enzyme motions by solution NMR relaxation dispersion.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The mechanism of rate-limiting motions in enzyme function.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Dynamic personalities of proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The changing landscape of protein allostery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Network of coupled promoting motions in enzyme catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Network analysis of protein dynamics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allostery without conformational change. A plausible model

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Is allostery an intrinsic property of all dynamic proteins?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The role of dynamics in allosteric regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Catalysis and binding of cyclophilin A with different HIV-1 capsid constructs

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Evidence for flexibility in the function of ribonuclease A

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

HIV-1 protease: structure, dynamics, and inhibition

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Free-energy landscape of enzyme catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Intrinsic motions along an enzymatic reaction trajectory

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Functional dynamics of human FKBP12 revealed by methyl 13C rotating frame relaxation dispersion NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The linkage between protein folding and functional cooperativity: two sides of the same coin?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Local motions in a benchmark of allosteric proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Ligand binding and internal equilibiums in proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Can allosteric regulation be predicted from structure?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Coupling between global dynamics and signal transduction pathways: a mechanism of allostery for chaperonin GroEL.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A Network of Conserved Interactions Regulates the Allosteric Signal in a Glutamine Amidotransferase†

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosteric cooperativity in protein kinase A.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Contact rearrangements form coupled networks from local motions in allosteric proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Structural identification of the pathway of long-range communication in an allosteric enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Dynamic Allostery in the Ring Protein TRAP

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

IIAGlc inhibition of glycerol kinase: a communications network tunes protein motions at the allosteric site

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Signal transduction pathway of TonB-dependent transporters

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosteric determinants in guanine nucleotide-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Evolutionarily conserved pathways of energetic connectivity in protein families

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Structural determinants of allosteric ligand activation in RXR heterodimers.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Reassessing a sparse energetic network within a single protein domain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Metal import through microbial membranes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Dynamically driven protein allostery.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Insulin allosteric behavior: detection, identification, and quantification of allosteric states via 19F NMR.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Using molecular dynamics to map interaction networks in an aminoacyl-tRNA synthetase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Propagation of Dynamic Changes in Barnase Upon Binding of Barstar: An NMR and Computational Study

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Caspase inhibition, specifically

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosteric modulation of nicotinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: a critical assessment

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosterism and cannabinoid CB(1) receptors: the shape of things to come

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Networks for the allosteric control of protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Searching for new allosteric sites in enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Tethering: fragment-based drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Site-specific incorporation of allosteric-inhibition sites in a protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Engineering allosteric protein switches by domain insertion

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Engineering synthetic signaling proteins with ultrasensitive input/output control

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Reprogramming control of an allosteric signaling switch through modular recombination

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A molecular switch created by in vitro recombination of nonhomologous genes.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Structure networks of E. coli glutaminyl-tRNA synthetase: effects of ligand binding.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Beginnings of feedback inhibition, allostery, and multi-protein complexes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Spin glasses and the statistical mechanics of protein folding

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.98

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.98

1 reference

21 June 2017

1 reference

PubMed ID

18641628