Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. (Q30382851)

14 September 2017

Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. (English)

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14 September 2017

John R Engen

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author name string

Christopher R Morgan

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1

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14 September 2017

1 November 2009

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Current protocols in protein science / editorial board John E. Coligan ... [et al.]

14 September 2017

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14 September 2017

Chapter 17

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14 September 2017

Unit 17.6.1-17

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HD desktop: an integrated platform for the analysis and visualization of H/D exchange data

14 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

"TOF2H": a precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI approach, covering the data pipeline from spectral acquisition to HDX rate analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

High-speed and high-resolution UPLC separation at zero degrees Celsius

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Hydrogen/deuterium exchange-mass spectrometry: a powerful tool for probing protein structure, dynamics and interactions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Semi-automated data processing of hydrogen exchange mass spectra using HX-Express

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Partial unfolding of diverse SH3 domains on a wide timescale

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Capsid structure and dynamics of a human rhinovirus probed by hydrogen exchange mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Hydrogen/deuterium exchange mass spectrometry for investigating protein-ligand interactions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Use of different proteases working in acidic conditions to improve sequence coverage and resolution in hydrogen/deuterium exchange of large proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Protein analysis by hydrogen exchange mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Factors affecting gas-phase deuterium scrambling in peptide ions and their implications for protein structure determination.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Investigating the higher order structure of proteins. Hydrogen exchange, proteolytic fragmentation, and mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayers.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

The hydrogen exchange core and protein folding.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Detection of transient protein folding populations by mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Primary structure effects on peptide group hydrogen exchange

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Effect of irreversibility on the thermodynamic characterization of the thermal denaturation of Aspergillus saitoi acid proteinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Hydrogen exchange and the dynamic structure of proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Hydrogen exchange and structural dynamics of proteins and nucleic acids

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

20 June 2018

12 December 2020

Hydrogen Exchange in Proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Primary structure effects on peptide group hydrogen exchange.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Purification and Characterization of Chicken Pepsinogen and Chicken Pepsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Protein hydrogen exchange studied by the fragment separation method.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: Application to ribonuclease S peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844867

Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

20 June 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Is there hydrogen scrambling in the gas phase? Energetic and structural determinants of proton mobility within protein ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Site-specific amide hydrogen/deuterium exchange in E. coli thioredoxins measured by electrospray ionization mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Conformational dynamics of the GdmHCl-induced molten globule state of creatine kinase monitored by hydrogen exchange and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Equilibrium and kinetic folding of rabbit muscle triosephosphate isomerase by hydrogen exchange mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Extensive Deuterium Back-Exchange in Certain Immobilized Pepsin Columns Used for H/D Exchange Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471140864.PS1706S58

Mass spectrometric determination of isotopic exchange rates of amide hydrogens located on the surfaces of proteins

21 January 2018

1 reference

12 December 2020

Kinetics of cytochrome c folding examined by hydrogen exchange and mass spectrometry

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12 December 2020

Identification of unfolding domains in large proteins by their unfolding rates

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12 December 2020

Comparison of continuous and pulsed labeling amide hydrogen exchange/mass spectrometry for studies of protein dynamics

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12 December 2020

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

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12 December 2020

Practical methods for deuterium exchange/mass spectrometry

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12 December 2020

Rate and equilibrium constants for protein unfolding and refolding determined by hydrogen exchange-mass spectrometry

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12 December 2020

Protein internal flexibility and global stability: effect of urea on hydrogen exchange rates of bovine pancreatic trypsin inhibitor

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12 December 2020

Protein stability parameters measured by hydrogen exchange

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12 December 2020

Hydrogen exchange-mass spectrometry: optimization of digestion conditions

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12 December 2020

Maize (Zea mays)-derived bovine trypsin: characterization of the first large-scale, commercial protein product from transgenic plants

1 reference

12 December 2020

Amide hydrogen exchange determined by mass spectrometry: application to rabbit muscle aldolase

1 reference

12 December 2020

10.1002/0471140864.PS1706S58

Identifiers

DOI

1 reference

14 September 2017

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PMC publication ID

2844867

14 September 2017

PubMed publication ID

19937720

1 reference

PMC publication ID

2844867