Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. (Q30388201)

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2 March 2020

title

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex (English)

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2 March 2020

1

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2 March 2020

Geoffrey A Smith

3

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2 March 2020

author name string

Steven G Sethofer

2

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2 March 2020

Howard R Miller

4

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2 March 2020

Jillian L Simard

5

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2 March 2020

William C Merrick

6

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2 March 2020

Rishi K Jain

7

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2 March 2020

Nathan T Ross

8

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2 March 2020

Jack Taunton

9

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2 March 2020

language of work or name

English

0 references

publication date

10 December 2015

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2 March 2020

1 reference

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2 March 2020

volume

4

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Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties

2 March 2020

cites work

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Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

20 June 2018

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Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

20 June 2018

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Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

20 June 2018

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How proteins bind macrocycles.

20 June 2018

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Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?

20 June 2018

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Target Identification by Diazirine Photo-Cross-linking and Click Chemistry

20 June 2018

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20 June 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

20 June 2018

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Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases

20 June 2018

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Inhibition of translation by cytotrienin A--a member of the ansamycin family

20 June 2018

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Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex

20 June 2018

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Enzymatic assembly of DNA molecules up to several hundred kilobases

20 June 2018

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Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes

20 June 2018

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The exploration of macrocycles for drug discovery--an underexploited structural class

20 June 2018

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Preparation and evaluation of acylated tRNAs.

20 June 2018

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Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the beta-OH-D-Leu(7) moiety

20 June 2018

1 reference

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Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

20 June 2018

1 reference

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Kinetics of the interactions between yeast elongation factors 1A and 1Balpha, guanine nucleotides, and aminoacyl-tRNA.

20 June 2018

1 reference

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Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1

20 June 2018

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Elongation factors in protein biosynthesis

20 June 2018

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Natural products as probes of cell biology: 20 years of didemnin research

20 June 2018

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Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox

20 June 2018

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FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

20 June 2018

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Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

20 June 2018

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

20 June 2018

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20 June 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

20 June 2018

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20 June 2018

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A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum

20 June 2018

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Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties

21 January 2018

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The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase

21 January 2018

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Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue

21 January 2018

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Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.

21 January 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 January 2018

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Convergent synthesis and in vivo inhibitory effect on fat accumulation of (-)-ternatin, a highly N-methylated cyclic peptide

21 January 2018

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12 December 2020

Purification of various forms of elongation factor 1 from rabbit reticulocytes

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12 December 2020

GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha

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12 December 2020

Inhibition of protein synthesis by didemnin B: how EF-1alpha mediates inhibition of translocation

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12 December 2020

Mechanism of protein synthesis inhibition by didemnin B in vitro

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12 December 2020

Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.10222

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26651998%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26651998%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference