Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB (Q30411815)

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12 February 2020

title

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB (English)

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12 February 2020

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Eiso Ab

5

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John H Bushweller

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author name string

Virginie Früh

1

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12 February 2020

Dan Chen

3

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Caroline Loch

4

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Yelena N Grinkova

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Herman Verheij

7

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Stephen G Sligar

8

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Gregg Siegal

10

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publication date

1 August 2010

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12 February 2020

published in

Chemistry and Biology

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volume

17

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issue

8

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page(s)

881-891

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NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation

12 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Integration of fragment screening and library design

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

A decade of fragment-based drug design: strategic advances and lessons learned

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Development of a dual cell, flow-injection sample holder, and NMR probe for comparative ligand-binding studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Progress and problems in the exploration of therapeutic targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Fragment-based lead discovery: leads by design

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

TINS, target immobilized NMR screening: an efficient and sensitive method for ligand discovery

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

A ‘Rule of Three’ for fragment-based lead discovery?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Direct solubilization of heterologously expressed membrane proteins by incorporation into nanoscale lipid bilayers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Paradoxical redox properties of DsbB and DsbA in the protein disulfide-introducing reaction cascade.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Refolded outer membrane protein A of Escherichia coli forms ion channels with two conductance states in planar lipid bilayers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Discovering high-affinity ligands for proteins: SAR by NMR

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

A pathway for disulfide bond formation in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Amphipol-assisted in vitro folding of G protein-coupled receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Insertion of membrane proteins into discoidal membranes using a cell-free protein expression approach.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Spectral unraveling by space-selective Hadamard spectroscopy

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Ligand efficiency indices as guideposts for drug discovery.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

DsbB catalyzes disulfide bond formation de novo

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104428

Discovering high-affinity ligands for proteins

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20797617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxidative protein folding is driven by the electron transport system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20797617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Disulfide bonds are generated by quinone reduction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20797617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2010.06.011

1 reference

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12 February 2020

1 reference

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12 February 2020

PubMed publication ID

20797617

1 reference