Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake (Q30412686)

16 August 2017

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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake (English)

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16 August 2017

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43

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Kathleen Stirrups

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Jorma Viikari

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Alexis C Frazier-Wood

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Nita G. Forouhi

Nita G Forouhi

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Paul W. Franks

Paul W Franks

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Stephen B Kritchevsky

Stephen B Kritchevsky

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Oscar H Franco

Oscar H Franco

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Jerome I Rotter

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Jerome I Rotter

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Frank B Hu

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Stavroula Kanoni

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Kay-Tee Khaw

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Kay-Tee Khaw

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Nicholas J Wareham

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Ruth J F Loos

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Luigi Ferrucci

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Frida Renstrom

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Yongmei Liu

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Andrew Singleton

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Lu Qi

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Goran Hallmans

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Richard D Semba

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Stefania Bandinelli

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David S Siscovick

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Donna K Arnett

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Ingrid B Borecki

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Kari E North

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Mary F Feitosa

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Daniel I Chasman

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Jacqueline C M Witteman

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Jacqueline C M Witteman

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Nicola M McKeown

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L Adrienne Cupples

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M Carola Zillikens

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Rozenn N Lemaitre

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Toshiko Tanaka

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Denise K Houston

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Julius S Ngwa

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Mary K Wojczynski

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Kurt K Lohman

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Olli Raitakari

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16 August 2017

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Zheng Ye

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Ioanna-Panagiota Kalafati

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Ioanna-Panagiota Kalafati

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Audrey Y Chu

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Ani Manichaikul

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Ingegerd Johansson

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Jennifer A Nettleton

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Marcia C de Oliveira Otto

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Marcia C de Oliveira Otto

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Maria Dimitriou

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Jennifer A Schrack

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Andrew Johnson

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Frank J A van Rooij

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Jian'an Luan

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Jing Hua Zhao

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Emily J Dhurandhar

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Valur Emilsson

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16 August 2017

language of work or name

English

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publication date

1 May 2013

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American Journal of Clinical Nutrition

16 August 2017

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16 August 2017

97

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6

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16 August 2017

1395-1402

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Novel locus including FGF21 is associated with dietary macronutrient intake

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Multiple loci are associated with white blood cell phenotypes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

METAL: fast and efficient meta-analysis of genomewide association scans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Geographical genomics of human leukocyte gene expression variation in southern Morocco

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Fibroblast growth factor 21: from pharmacology to physiology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

An obesity-associated FTO gene variant and increased energy intake in children

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Variation in the FTO gene influences food intake but not energy expenditure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

The fat mass- and obesity-associated locus and dietary intake in children

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Mapping the genetic architecture of gene expression in human liver

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Genetics of gene expression and its effect on disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A new multipoint method for genome-wide association studies by imputation of genotypes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Variation in FTO contributes to childhood obesity and severe adult obesity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Genetics of food intake and eating behavior phenotypes in humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

FGF-21 as a novel metabolic regulator

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

The Nurses' Health Study: lifestyle and health among women

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Prospective study of alcohol consumption and risk of coronary disease in men.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Dopamine D2 receptor genotype (C957T) and habitual consumption of sugars in a free-living population of men and women

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Evidence of a quantitative trait locus for energy and macronutrient intakes on chromosome 3q27.3: the Quebec Family Study.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A Quantitative Trait Locus on Chromosome 18q for Physical Activity and Dietary Intake in Hispanic Children*

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Polymorphism of the 5-HT2A receptor gene and food intakes in children and adolescents: the Stanislas Family Study.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Relation between food reinforcement and dopamine genotypes and its effect on food intake in smokers

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3652928

Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

26 November 2018

1 reference

12 December 2020

A Variant in the Fat Mass and Obesity-Associated Gene (FTO) and Variants near the Melanocortin-4 Receptor Gene (MC4R) Do Not Influence Dietary Intake

1 reference

12 December 2020

5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people

1 reference

12 December 2020

Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22

1 reference

12 December 2020

Identifiers

DOI

10.3945/AJCN.112.052183

1 reference

16 August 2017

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16 August 2017

PubMed publication ID

23636237

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