The design and proof of concept for a CD8(+) T cell-based vaccine inducing cross-subtype protection against influenza A virus (Q30423530)

21 June 2017

The design and proof of concept for a CD8(+) T cell-based vaccine inducing cross-subtype protection against influenza A virus (English)

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2,3-dipalmitoyl-S-glycerylcysteine

21 June 2017

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ChEBI release 2020-05-28

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influenza A virus

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6

David C Jackson

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21 June 2017

Amabel C L Tan

1

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21 June 2017

Georgia Deliyannis

2

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21 June 2017

Mandvi Bharadwaj

3

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21 June 2017

Lorena E Brown

4

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21 June 2017

Weiguang Zeng

5

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21 June 2017

language of work or name

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13 November 2012

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Immunology & Cell Biology

21 June 2017

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21 June 2017

91

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21 June 2017

1

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21 June 2017

96-104

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Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus

21 June 2017

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Characterization of the 1918 influenza virus polymerase genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Heterologous protection against lethal A/HongKong/156/97 (H5N1) influenza virus infection in C57BL/6 mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Profound protection against respiratory challenge with a lethal H7N7 influenza A virus by increasing the magnitude of CD8(+) T-cell memory

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Cytotoxic T-cell immunity to influenza.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lymphocyte populations directed to human influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

HLA class I supertypes: a revised and updated classification

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cells in the control of highly virulent influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Intranasal lipopeptide primes lung-resident memory CD8+ T cells for long-term pulmonary protection against influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

The influenza virus resource at the National Center for Biotechnology Information

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Ab and T cell epitopes of influenza A virus, knowledge and opportunities

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Human memory CTL response specific for influenza A virus is broad and multispecific

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

HLA-B*0702 transgenic, H-2KbDb double-knockout mice: phenotypical and functional characterization in response to influenza virus

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Identifiying human MHC supertypes using bioinformatic methods.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Definition of supertypes for HLA molecules using clustering of specificity matrices.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Precursor frequency and competition dictate the HLA-A2-restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Functional supertype of HLA-A2 in the presentation of Flu matrix p58-66 to induce CD8+ T-cell response in a Northern Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

A mutation in the HLA-B*2705-restricted NP383-391 epitope affects the human influenza A virus-specific cytotoxic T-lymphocyte response in vitro

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

T-cell memory and recall responses to respiratory virus infections

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Virus-specific CD8+ T cells in primary and secondary influenza pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Preferential migration of effector CD8+ T cells into the interstitium of the normal lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Protection against a European H1N2 swine influenza virus in pigs previously infected with H1N1 and/or H3N2 subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Influence of a single viral epitope on T cell response and disease after infection of mice with respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

High-yield reassortant influenza vaccine production virus has a mutation at an HLA-A 2.1-restricted CD8+ CTL epitope on the NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Immunodominant peptides from conserved influenza proteins--a tool for more efficient vaccination in the elderly?

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2012.54

Annual vaccination against influenza virus hampers development of virus-specific CD8⁺ T cell immunity in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Vaccination against seasonal influenza A/H3N2 virus reduces the induction of heterosubtypic immunity against influenza A/H5N1 virus infection in ferrets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Memory CD4+ T cells induce innate responses independently of pathogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Structural requirement for the agonist activity of the TLR2 ligand Pam2Cys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Intranasal Administration of the TLR2 Agonist Pam2Cys Provides Rapid Protection against Influenza in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

High frequency of HLA-A*0207 subtype in Chinese population

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

T cell responses are better correlates of vaccine protection in the elderly

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigens

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.54

7 January 2021

Identifiers

DOI

10.1038/ICB.2012.54

1 reference

Dimensions Publication ID

21 June 2017

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