Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease (Q30426102)

12 August 2017

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease (English)

1 reference

neglected tropical disease

12 August 2017

0 references

1 reference

5 February 2019

adenylate kinase, putative

1 reference

5 February 2019

trypanothione reductase

1 reference

ATP synthase F1, alpha subunit, putative

5 February 2019

1 reference

methylthioadenosine phosphorylase, putative

5 February 2019

1 reference

lanosterol synthase, putative

5 February 2019

1 reference

dihydrofolate reductase-thymidylate synthase

5 February 2019

1 reference

Lanosterol 14-alpha demethylase

5 February 2019

1 reference

ornithine decarboxylase, putative

5 February 2019

1 reference

squalene monooxygenase-like protein

5 February 2019

1 reference

mevalonate-diphosphate decarboxylase, putative

5 February 2019

1 reference

phosphoglycerate kinase C, glycosomal

5 February 2019

1 reference

thymidine kinase, putative

5 February 2019

1 reference

ribonucleoside-diphosphate reductase small chain, putative

5 February 2019

1 reference

farnesyl pyrophosphate synthase

5 February 2019

1 reference

triosephosphate isomerase

5 February 2019

1 reference

aldehyde dehydrogenase, mitochondrial precursor

5 February 2019

1 reference

ATP synthase subunit beta, mitochondrial, putative

5 February 2019

1 reference

ATP synthase subunit beta, mitochondrial, putative

5 February 2019

1 reference

ribonucleoside-diphosphate reductase small chain, putative

5 February 2019

1 reference

3-hydroxy-3-methylglutaryl-CoA reductase

5 February 2019

1 reference

PAS-domain containing phosphoglycerate kinase, putative

6 February 2019

1 reference

S-adenosylmethionine synthetase

6 February 2019

1 reference

squalene synthase, putative

6 February 2019

1 reference

6 February 2019

phosphomannose isomerase

1 reference

3-oxoacyl-acyl carrier protein synthase ii, putative

6 February 2019

1 reference

adenylate kinase, putative

6 February 2019

1 reference

6-phosphogluconate dehydrogenase, decarboxylating, putative

6 February 2019

1 reference

6 February 2019

1 reference

Jason A Papin

6

0 references

author name string

Arvind K Chavali

1

1 reference

12 August 2017

Anna S Blazier

2

1 reference

12 August 2017

Jose L Tlaxca

3

1 reference

12 August 2017

Paul A Jensen

4

1 reference

12 August 2017

Richard D Pearson

5

1 reference

12 August 2017

27 April 2012

1 reference

12 August 2017

1 reference

12 August 2017

6

1 reference

12 August 2017

27

1 reference

Recent initiatives and strategies to developing new drugs for tropical parasitic diseases

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Differential effects of paromomycin on ribosomes of Leishmania mexicana and mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Blueprint for antimicrobial hit discovery targeting metabolic networks

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Applications of genome-scale metabolic reconstructions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Synergistic drug combinations tend to improve therapeutically relevant selectivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Rescuing the bottom billion through control of neglected tropical diseases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Mass drug administration and integrated control for the world's high-prevalence neglected tropical diseases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Molecular basis of antimony treatment in leishmaniasis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Genomic-scale prioritization of drug targets: the TDR Targets database

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Rapid fluorescent assay for screening drugs on Leishmania amastigotes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

14 July 2018

New uses for old drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Chemotherapy of leishmaniasis: past, present and future

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

A mathematical approach to study combined effects of toxicants in vitro: evaluation of the Bliss independence criterion and the Loewe additivity model.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Novel compounds active against Leishmania major

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Challenges and new discoveries in the treatment of leishmaniasis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Practical progress and new drugs for changing patterns of leishmaniasis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Leishmaniasis: current situation and new perspectives

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Treatment of cutaneous leishmaniasis among travellers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

The effects of alternate optimal solutions in constraint-based genome-scale metabolic models

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Topical treatment for cutaneous leishmaniasis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Metronidazole and Indian kala-azar: results of a clinical trial

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Terbinafine: mode of action and properties of the squalene epoxidase inhibition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

Placebo-Controlled Clinical Trial of Sodium Stibogluconate (Pentostam) versus Ketoconazole for Treating Cutaneous Leishmaniasis in Guatemala

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

A Global Fund to Fight Neglected Tropical Diseases: is the G8 Hokkaido Toyako 2008 Summit ready?

14 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-6-27

Itraconazole and leishmaniasis: a randomised double-blind trial in cutaneous disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-6-27

Terbinafine in the treatment of cutaneous leishmaniasis: a pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-6-27

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-6-27

A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1752-0509-6-27

Antileishmanial activity of azithromycin against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

A phase II dose-increasing study of sitamaquine for the treatment of visceral leishmaniasis in Kenya

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388006

A randomized, double-blind, clinical trial of topical clotrimazole versus miconazole for treatment of cutaneous leishmaniasis in the eastern province of Saudi Arabia

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22540944

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22540944

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1752-0509-6-27

1 reference

journals/bmcsb/ChavaliBTJPP12

12 August 2017

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

0 references

1 reference

12 August 2017

PubMed publication ID

22540944

1 reference