Design, Synthesis, and Biological Evaluation of PKD Inhibitors (Q30428751)

21 September 2017

Design, Synthesis, and Biological Evaluation of PKD Inhibitors (English)

1 reference

21 September 2017

8

John S Lazo

1 reference

21 September 2017

10

Peter Wipf

1 reference

21 September 2017

7

Elizabeth R Sharlow

1 reference

21 September 2017

6

Stephanie Leimgruber

1 reference

21 September 2017

5

Manuj Tandon

1 reference

21 September 2017

2

Marie-Céline Frantz

1 reference

21 September 2017

Karla Bravo-Altamirano

series ordinal

3

object named as

Karla Bravo-Altamirano

1 reference

21 September 2017

4

Courtney R Lavalle

1 reference

21 September 2017

Kara M George

1

1 reference

21 September 2017

Q Jane Wang

series ordinal

9

1 reference

21 September 2017

1 January 2011

1 reference

21 September 2017

1 reference

21 September 2017

3

1 reference

21 September 2017

2

1 reference

21 September 2017

186-228

1 reference

Creative Commons Attribution 4.0 International

21 September 2017

start time

21 April 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D as a potential new target for cancer therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Requirement of protein kinase D1 for pathological cardiac remodeling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

PKD at the crossroads of DAG and PKC signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Design, synthesis, and development of novel caprolactam anticonvulsants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Phosphorylation-dependent protein kinase D activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

PKCu is a novel, atypical member of the protein kinase C family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Characterization of activators and inhibitors of protein kinase C mu.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261798

Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.

20 June 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Cell biology. Slick recruitment to the Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

p38delta and PKD1: kinase switches for insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Inhibition of protein kinase D by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Synthesis of Peptide Isocyanates and Isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FPHARMACEUTICS3020186

Protein kinase D: activation for Golgi carrier formation

21 January 2018

1 reference

12 December 2020

Protein kinase C mu is down-regulated in androgen-independent prostate cancer

1 reference

12 December 2020

Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages

1 reference

12 December 2020

A New Kid on the Block

1 reference

12 December 2020

Intracellular Location and Cell Context-Dependent Function of Protein Kinase D

1 reference

12 December 2020

Regio- and chemoselective synthesis of fully substituted thiophenes

1 reference

12 December 2020

Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu

1 reference

12 December 2020

Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

1 reference

12 December 2020

From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists

1 reference

12 December 2020

10.3390/PHARMACEUTICS3020186

Identifiers

DOI

1 reference

21 September 2017

1 reference

21 September 2017

PubMed publication ID

22267986

1 reference