Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation (Q30440592)

17 August 2017

Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation (English)

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17 August 2017

1 reference

Nitish Agrawal

1

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author name string

Ruma Banerjee

series ordinal

2

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PMCID

2606060

17 August 2017

language of work or name

English

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publication date

24 December 2008

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17 August 2017

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17 August 2017

3

1 reference

17 August 2017

12

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17 August 2017

e4032

1 reference

Creative Commons Attribution 4.0 International

17 August 2017

start time

24 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase

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Small ubiquitin-related modifiers in chains

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20 June 2018

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Concepts in sumoylation: a decade on

20 June 2018

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Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction

20 June 2018

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Polycomb comes of age: genome-wide profiling of target sites

20 June 2018

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Glutathione is recruited into the nucleus in early phases of cell proliferation.

20 June 2018

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Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway

20 June 2018

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A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

20 June 2018

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Genome regulation by polycomb and trithorax proteins

20 June 2018

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Human cystathionine beta-synthase is a target for sumoylation

20 June 2018

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Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

20 June 2018

1 reference

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S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity

20 June 2018

1 reference

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A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation

20 June 2018

1 reference

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Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin

20 June 2018

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Sumoylation silences the plasma membrane leak K+ channel K2P1.

20 June 2018

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Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors

20 June 2018

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Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

20 June 2018

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Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine

20 June 2018

1 reference

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Regulation and function of SUMO modification

20 June 2018

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Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations

20 June 2018

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The polycomb protein Pc2 is a SUMO E3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus

20 June 2018

1 reference

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Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Polycomb repression: from cellular memory to cellular proliferation and cancer.

20 June 2018

1 reference

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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Cystathionine beta-synthase mutations in homocystinuria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606060

Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004032

Glutathione regulates telomerase activity in 3T3 fibroblasts

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004032

Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004032

Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19107218

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19107218

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0004032

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference

PMCID

2606060