Mechanotransduction in human bone: in vitro cellular physiology that underpins bone changes with exercise (Q30441817)

21 August 2017

1 reference

title

Mechanotransduction in human bone: in vitro cellular physiology that underpins bone changes with exercise (English)

1 reference

21 August 2017

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Alexander Scott

1

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21 August 2017

Karim M Khan

series ordinal

2

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21 August 2017

Vincent Duronio

series ordinal

3

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21 August 2017

David A Hart

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4

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21 August 2017

language of work or name

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1 January 2008

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21 August 2017

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21 August 2017

38

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21 August 2017

2

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21 August 2017

139-160

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https://scigraph.springernature.com/pub.10.2165/00007256-200838020-00004

21 August 2017

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Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts

20 June 2018

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Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Pertussis toxin‐sensitive Gαi protein and ERK‐dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts1

20 June 2018

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Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line

20 June 2018

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Tensegrity II. How structural networks influence cellular information processing networks

20 June 2018

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Tensegrity I. Cell structure and hierarchical systems biology

20 June 2018

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Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation.

20 June 2018

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Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells

20 June 2018

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ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts

20 June 2018

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Mechanical strain and bone cell function: a review

20 June 2018

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Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain

20 June 2018

1 reference

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Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation.

20 June 2018

1 reference

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

20 June 2018

1 reference

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Force transduction by Triton cytoskeletons

20 June 2018

1 reference

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Shear force modulates osteoblast response to surface roughness

20 June 2018

1 reference

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Mechanically induced ATP release from human osteoblastic cells

20 June 2018

1 reference

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Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels

20 June 2018

1 reference

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Mechanical strain and estrogen activate estrogen receptor alpha in bone cells

20 June 2018

1 reference

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Brefeldin A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction

20 June 2018

1 reference

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Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women

20 June 2018

1 reference

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TNF-alpha-dependent activation of NF-kappa B in human osteoblastic HOS-TE85 cells is repressed in vector-averaged gravity using clinostat rotation

20 June 2018

1 reference

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Selected contribution: regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells

20 June 2018

1 reference

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Mechanical control of cyclic AMP signalling and gene transcription through integrins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Human bone cell hyperpolarization response to cyclical mechanical strain is mediated by an interleukin-1beta autocrine/paracrine loop.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanical manipulation of bone and cartilage cells with 'optical tweezers'.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Analysis of spatial distributions of cellular molecules during mechanical stressing of cell surface receptors using confocal microscopy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: modulation by cation channel blockades

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Gene expression related to the differentiation of osteoblastic cells is altered by microgravity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Effects of simulated microgravity on human osteoblast-like cells in culture

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Electrophysiological responses of human bone cells to mechanical stimulation: evidence for specific integrin function in mechanotransduction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Calcium waves in fluid flow stimulated osteoblasts are G protein mediated

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Membrane stretch activates a high-conductance K+ channel in G292 osteoblastic-like cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media

20 June 2018

1 reference

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https://api.crossref.org/works/10.2165%2F00007256-200838020-00004

The predominant mechanism of intercellular calcium wave propagation changes during long-term culture of human osteoblast-like cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Regulation of bone mass and bone turnover by neuronal nitric oxide synthase.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Shear stress inhibits while disuse promotes osteocyte apoptosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Fluid shear of low magnitude increases growth and expression of TGFbeta1 and adhesion molecules in human bone cells in vitro

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanical regulation of HB-GAM expression in bone cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Secretion of osteopontin from MG-63 cells under a physiological level of mechanical strain in vitro--a [35S] incorporation approach.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Effects of substrate characteristics on bone cell response to the mechanical environment.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Physiological strains remodel extracellular matrix and cell-cell adhesion in osteoblastic cells cultured on alumina-coated titanium alloy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Physiological strains induce differentiation in human osteoblasts cultured on orthopaedic biomaterial

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

The role of the cytoskeleton in mechanotransduction in human osteoblast-like cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

The mode of mechanical integrin stressing controls intracellular signaling in osteoblasts

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Fluid shear stress increases interleukin-11 expression in human osteoblast-like cells: its role in osteoclast induction.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Response of normal and osteoporotic human bone cells to mechanical stress in vitro.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Mineralization and the expression of matrix proteins during in vivo bone development

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951486

Cyclic stretching of human osteoblasts affects proliferation and metabolism: a new experimental method and its application

26 November 2018

1 reference

12 December 2020

Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k)

1 reference

12 December 2020

Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2)

1 reference

12 December 2020

Intercellular Calcium Signaling Occurs between Human Osteoblasts and Osteoclasts and Requires Activation of Osteoclast P2X7 Receptors

1 reference

12 December 2020

Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats

1 reference

12 December 2020

Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes

1 reference

12 December 2020

Bone matrix RGD glycoproteins: immunolocalization and interaction with human primary osteoblastic bone cells in vitro

1 reference

12 December 2020

Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro

1 reference

12 December 2020

Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation

1 reference

12 December 2020

In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes

1 reference

12 December 2020

Multiple forms of mechanosensitive ion channels in osteoblast-like cells

1 reference

12 December 2020

Human osteoblasts from younger normal and osteoporotic donors show differences in proliferation and TGF beta-release in response to cyclic strain

1 reference

12 December 2020

A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction

1 reference

12 December 2020

Mechanical stress induces COX-2 mRNA expression in bone cells from elderly women

1 reference

12 December 2020

Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells

1 reference

12 December 2020

The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells

1 reference

12 December 2020

Human osteoblastic cells propagate intercellular calcium signals by two different mechanisms

1 reference

12 December 2020

Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates

1 reference

12 December 2020

Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine

1 reference

12 December 2020

Regulation of human osteoblast integrin expression by orthopedic implant materials

1 reference

12 December 2020

Primary adult human bone cells do not respond to tissue (continuum) level strains

1 reference

12 December 2020

Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells

1 reference

12 December 2020

A comparison of type I collagen, fibronectin, and vitronectin in supporting adhesion of mechanically strained osteoblasts

1 reference

12 December 2020

Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation

1 reference

12 December 2020

Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent

1 reference

12 December 2020

10.2165/00007256-200838020-00004

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DOI

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21 August 2017

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1 reference

21 August 2017

1 reference