Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. (Q30465575)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

5

Douglas R Cavener

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Mimi A Trinh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Hanoch Kaphzan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Ronald C Wek

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Eric Klann

6

1 reference

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8 February 2020

publication date

24 May 2012

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8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

676-688

1 reference

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8 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition

8 February 2020

cites work

1 reference

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Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs

14 July 2018

1 reference

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Two novel mutations in the EIF2AK3 gene in children with Wolcott-Rallison syndrome

14 July 2018

1 reference

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GABAergic interneuron origin of schizophrenia pathophysiology.

14 July 2018

1 reference

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Wolcott-Rallison syndrome

14 July 2018

1 reference

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Cognitive control deficits in schizophrenia: mechanisms and meaning

14 July 2018

1 reference

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Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

14 July 2018

1 reference

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

14 July 2018

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α-Synuclein: membrane interactions and toxicity in Parkinson's disease

14 July 2018

1 reference

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eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.

14 July 2018

1 reference

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The mechanism of eukaryotic translation initiation and principles of its regulation

14 July 2018

1 reference

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mTOR signaling: at the crossroads of plasticity, memory and disease

14 July 2018

1 reference

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Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

14 July 2018

1 reference

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Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families

14 July 2018

1 reference

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The neural substrates of cognitive control deficits in autism spectrum disorders

14 July 2018

1 reference

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Translational control of long-lasting synaptic plasticity and memory

14 July 2018

1 reference

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Making synaptic plasticity and memory last: mechanisms of translational regulation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

14 July 2018

1 reference

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The Autistic Neuron: Troubled Translation?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Realistic expectations of prepulse inhibition in translational models for schizophrenia research

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Disrupted-in-Schizophrenia-1.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Glycine transport inhibitors and the treatment of schizophrenia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The DISC locus in psychiatric illness

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction.

14 July 2018

1 reference

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Translational regulatory mechanisms in persistent forms of synaptic plasticity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

A systematic genomewide linkage study in 353 sib pairs with schizophrenia

14 July 2018

1 reference

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Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Eukaryotic translation initiation factors and regulators

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The molecular biology of memory storage: a dialog between genes and synapses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Perk is essential for translational regulation and cell survival during the unfolded protein response

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Memory--a century of consolidation

14 July 2018

1 reference

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

14 July 2018

1 reference

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Memory suppressor genes: inhibitory constraints on the storage of long-term memory

14 July 2018

1 reference

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Subregion- and cell type-restricted gene knockout in mouse brain

14 July 2018

1 reference

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Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Developments of a water-maze procedure for studying spatial learning in the rat

14 July 2018

1 reference

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Recent advances in the phencyclidine model of schizophrenia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Validation and extension of the endophenotype model in ADHD patterns of inheritance in a family study of inhibitory control.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

SUnSET, a nonradioactive method to monitor protein synthesis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Associations of ATF4 gene polymorphisms with schizophrenia in male patients.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm.

26 November 2018

1 reference

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Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Multicenter linkage study of schizophrenia loci on chromosome 22q.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401382

Autopsy findings in the Wolcott-Rallison syndrome

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22813743

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2012.04.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22813743%20AND%20SRC:MED&resulttype=core&format=json