Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia. (Q30466262)

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English	Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.	scientific article

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22 January 2020

Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia (English)

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22 January 2020

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Caterina P Profaci

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22 January 2020

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Kristyn A Krolikowski

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22 January 2020

Rafal T Olszewski

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22 January 2020

Joseph H Neale

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22 January 2020

publication date

16 February 2011

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22 January 2020

Psychopharmacology

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22 January 2020

216

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22 January 2020

2

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22 January 2020

235-243

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22 January 2020

Type 2 metabotropic glutamate receptor (mGluR2) fails to negatively couple to cGMP in stably transfected cells

1 reference

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20 June 2018

Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.

1 reference

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20 June 2018

Sensing G protein-coupled receptor activation.

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20 June 2018

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase

1 reference

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20 June 2018

Molecular characterization of N-acetylaspartylglutamate synthetase

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20 June 2018

Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families

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20 June 2018

Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice

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20 June 2018

The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor

1 reference

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20 June 2018

Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR

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20 June 2018

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

1 reference

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20 June 2018

Relationship between PPI and baseline startle response

1 reference

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20 June 2018

Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain

1 reference

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20 June 2018

Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors

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20 June 2018

Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions

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20 June 2018

Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats

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20 June 2018

Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades

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20 June 2018

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration

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20 June 2018

A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity

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20 June 2018

The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia

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20 June 2018

Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart

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20 June 2018

The cloning and characterization of a second brain enzyme with NAAG peptidase activity

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20 June 2018

Animal behavior models of the mechanisms underlying antipsychotic atypicality

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20 June 2018

GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism

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20 June 2018

Metabotropic glutamate receptors: potential drug targets for the treatment of schizophrenia

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20 June 2018

Mouse genetic models for prepulse inhibition: an early review

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20 June 2018

Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus

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20 June 2018

G protein specificity: traffic direction required.

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20 June 2018

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

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20 June 2018

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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20 June 2018

NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance

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20 June 2018

Regulation of neurotransmitter release by metabotropic glutamate receptors

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20 June 2018

Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

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20 June 2018

N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system

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20 June 2018

LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

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20 June 2018

Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

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20 June 2018

Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II

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20 June 2018

Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library

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20 June 2018

The phencyclidine-glutamate model of schizophrenia.

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20 June 2018

Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase

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20 June 2018

Recent advances in the phencyclidine model of schizophrenia

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20 June 2018

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate

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21 January 2018

On the influence of baseline startle reactivity on the indexation of prepulse inhibition.

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21 January 2018

Metabotropic glutamate receptors modulate glutamatergic and GABAergic synaptic transmission in the central nucleus of the inferior colliculus

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21 January 2018

Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).

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21 January 2018

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

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21 January 2018

Effect of d-amphetamine on prepulse inhibition of the startle reflex in humans.

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21 January 2018

Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat.

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21 January 2018

Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.

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21 January 2018

Growth hormone-induced diacylglycerol and ceramide formation via Galpha i3 and Gbeta gamma in GH4 pituitary cells. Potentiation by dopamine-D2 receptor activation

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21 January 2018

Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat.

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21 January 2018

NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

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21 January 2018

First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients

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21 January 2018

Serotonin transporter, 5-HT1A receptor, and behavior in DBA/2J mice in comparison with four inbred mouse strains.

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21 January 2018

The effects of atypical antipsychotics and phencyclidine (PCP) on rotorod performance.

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21 January 2018

Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes

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21 January 2018

Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.

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21 January 2018

NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.

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26 November 2018

Assessment of murine startle reactivity, prepulse inhibition, and habituation

1 reference

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26 November 2018

beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor

1 reference

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26 November 2018

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108005

26 November 2018

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21327758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/21327758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21327758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S00213-011-2200-0

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21327758%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21327758%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

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Europe PubMed Central

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22 January 2020

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