Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. (Q30476291)

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8 January 2020

title

Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src (English)

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5

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Ssang-Taek Lim

2

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8 January 2020

Dusko Ilic

8

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8 January 2020

author name string

Datsun A Hsia

1

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8 January 2020

Joie A Bernard-Trifilo

3

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8 January 2020

Satyajit K Mitra

4

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Jeroen den Hertog

6

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8 January 2020

Daniel N Streblow

7

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Mark H Ginsberg

9

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David D Schlaepfer

10

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8 January 2020

language of work or name

English

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publication date

1 November 2005

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Molecular and Cellular Biology

8 January 2020

published in

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volume

25

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8 January 2020

page(s)

9700-9712

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issue

21

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Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1

8 January 2020

cites work

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Src kinase regulation by phosphorylation and dephosphorylation

20 June 2018

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An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells

20 June 2018

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Focal adhesion kinase: in command and control of cell motility

20 June 2018

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20 June 2018

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

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Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

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Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration

20 June 2018

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Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.

20 June 2018

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Focal adhesion kinase: the first ten years

20 June 2018

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Role of integrins in cell invasion and migration

20 June 2018

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Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration

20 June 2018

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Differential regulation of cell motility and invasion by FAK

20 June 2018

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Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin alpha4beta1 and cell adhesion in hematopoietic cells

20 June 2018

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PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration

20 June 2018

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Integrins: bidirectional, allosteric signaling machines

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20 June 2018

Fibronectin at a glance

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alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism

20 June 2018

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20 June 2018

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A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration

20 June 2018

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The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts

26 November 2018

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Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin

26 November 2018

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Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.

26 November 2018

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Involvement of the membrane distal catalytic domain in pervanadate-induced tyrosine phosphorylation of receptor protein-tyrosine phosphatase alpha.

26 November 2018

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Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK.

26 November 2018

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The type III connecting segment of fibronectin contains an aspartic acid residue that regulates the rate of binding to integrin alpha 4 beta 1.

26 November 2018

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26 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/16227616

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.25.21.9700-9712.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16227616%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16227616%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference