The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase (Q30478319)

12 September 2017

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase (English)

1 reference

12 September 2017

Lin Wang

1

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12 September 2017

Nina M Goodey

series ordinal

2

1 reference

12 September 2017

Stephen J Benkovic

series ordinal

3

1 reference

12 September 2017

Amnon Kohen

series ordinal

4

1 reference

12 September 2017

language of work or name

English

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publication date

1 August 2006

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12 September 2017

9

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Philosophical Transactions of the Royal Society B

inferred from page(s)

published in

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12 September 2017

361

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12 September 2017

1472

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12 September 2017

1307-1315

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Effects of a distal mutation on active site chemistry

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

How enzymes work: analysis by modern rate theory and computer simulations

20 June 2018

1 reference

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A perspective on enzyme catalysis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

20 June 2018

1 reference

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Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications

20 June 2018

1 reference

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Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

20 June 2018

1 reference

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Barrier passage and protein dynamics in enzymatically catalyzed reactions

20 June 2018

1 reference

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A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

20 June 2018

1 reference

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Network of coupled promoting motions in enzyme catalysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Dynamics of biochemical and biophysical reactions: insight from computer simulations

20 June 2018

1 reference

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Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Colworth Medal Lecture. Enzymes in the quantum world

20 June 2018

1 reference

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Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Hydrogen tunneling in biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Stretching exercises--flexibility in dihydrofolate reductase catalysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

A link between protein structure and enzyme catalyzed hydrogen tunneling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Steady-state analysis of kinetic isotope effects in enzymic reactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1647312

Microscale synthesis of 2-tritiated isopropanol and 4R-tritiated reduced nicotinamide adenine dinucleotide phosphate

20 June 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Importance of substrate and cofactor polarization in the active site of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Hydrogen tunneling in the flavoenzyme monoamine oxidase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Synthesis and utility of 14C-labeled nicotinamide cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Tunneling dynamics of double proton transfer in formic acid and benzoic acid dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2006.1871

Synthesis of R and S tritiated reduced beta-nicotinamide adenine dinucleotide 2' phosphate

21 January 2018

1 reference

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Double hydrogen tunneling revisited: the breakdown of experimental tunneling criteria

26 November 2018

1 reference

12 December 2020

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

1 reference

12 December 2020

Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp. 1-IN

1 reference

12 December 2020

A method of preparation and purification of (4R)-deuterated-reduced nicotinamide adenine dinucleotide phosphate

1 reference

12 December 2020

Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase

1 reference

12 December 2020

Use of deuterium labelled glucose in evaluating the pathway of hepatic glycogen synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSTB.2006.1871

1 reference

12 September 2017

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12 September 2017

PubMed publication ID

16873118

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