Affinity maturation of antibodies assisted by in silico modeling. (Q30482656)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18574150%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Affinity maturation of antibodies assisted by in silico modeling (English)

1 reference

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9 January 2020

1 reference

1 reference

1

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9 January 2020

J. Ignacio Casal

5

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9 January 2020

author name string

Johan Desmet

2

1 reference

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9 January 2020

Peter Timmerman

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18574150%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Rob Meloen

4

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9 January 2020

language of work or name

English

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publication date

23 June 2008

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9 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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9 January 2020

volume

105

1 reference

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9 January 2020

issue

26

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9 January 2020

page(s)

9029-9034

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18574150%20AND%20SRC:MED&resulttype=core&format=json

Designing antibodies for the inhibition of gastrin activity in tumoral cell lines.

9 January 2020

cites work

1 reference

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Engineering antibodies for clinical applications

20 June 2018

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Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation

20 June 2018

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Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

20 June 2018

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A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Potent antibody therapeutics by design

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Selection, design, and engineering of therapeutic antibodies

20 June 2018

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Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation.

20 June 2018

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A general method for greatly improving the affinity of antibodies by using combinatorial libraries

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

20 June 2018

1 reference

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In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Structural mechanism for affinity maturation of an anti-lysozyme antibody

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Fast and accurate side-chain topology and energy refinement (FASTER) as a new method for protein structure optimization.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Selection of large diversities of antiidiotypic antibody fragments by phage display

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Expression of gastrin in developing gastric adenocarcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Identification of functional and structural amino-acid residues by parsimonious mutagenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Growth-promoting effects of glycine-extended progastrin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Identification of gastrin as a growth peptide in human pancreatic cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Epitope mapping of a protein using the Geysen (PEPSCAN) procedure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Design, construction and function of a multicopy display vector using fusions to the major coat protein of bacteriophage M13.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

A phase II study of G17DT in gastric carcinoma

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801221105

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

21 January 2018

1 reference

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Therapeutic antibodies: magic bullets hit the target.

21 January 2018

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Paratope and Epitope Mapping of the Antithrombotic Antibody 6B4 in Complex with Platelet Glycoprotein Ibα

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801221105

Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody: 6B4.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449359

Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma

26 November 2018

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12 December 2020

Monoclonal antibody therapy of cancer

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12 December 2020

G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy

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12 December 2020

Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer

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12 December 2020

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0801221105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18574150%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18574150%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference