Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids (Q30487641)

22 June 2017

Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids (English)

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22 June 2017

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Trypanosomatids

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1

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22 June 2017

5

Jean-Robert Ioset

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22 June 2017

Louis Maes

2

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PubMed ID

25690568

22 June 2017

Leela Pavan Tadoori

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3

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PubMed ID

25690568

22 June 2017

Thomas Spangenberg

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4

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22 June 2017

17 February 2015

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Journal of Biomolecular Screening

22 June 2017

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22 June 2017

20

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22 June 2017

634-645

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22 June 2017

5

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Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

22 June 2017

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https://api.crossref.org/works/10.1177%2F1087057115569155

Drug resistance in leishmaniasis

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Tolerance and safety of nifurtimox in patients with chronic chagas disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Leishmaniasis: an update of current pharmacotherapy

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Thousands of chemical starting points for antimalarial lead identification

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Chemical genetics of Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

The open access malaria box: a drug discovery catalyst for neglected diseases

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Orally active antischistosomal early leads identified from the open access malaria box

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Lead- and drug-like compounds: the rule-of-five revolution

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

A comparison of three methods of estimating EC50 in studies of drug resistance of malaria parasites

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Use of isothermal microcalorimetry to monitor microbial activities.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

Folate metabolism in human malaria parasites--75 years on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057115569155

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Targeting trypanothione metabolism in trypanosomatid human parasites

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057115569155

21 January 2018

Identifiers

DOI

10.1177/1087057115569155

1 reference

22 June 2017

1 reference

PubMed ID

25690568