A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a. (Q30494532)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20299463%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a (English)

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21 January 2020

7

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21 January 2020

Simon Bernèche

2

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21 January 2020

6

Olivier Michielin

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21 January 2020

author name string

Luz Angélica Liechti

1

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21 January 2020

Benoîte Bargeton

3

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21 January 2020

Justyna Iwaszkiewicz

4

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21 January 2020

Sophie Roy

5

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21 January 2020

language of work or name

English

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publication date

18 March 2010

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Journal of Biological Chemistry

21 January 2020

number of pages

15

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based on heuristic

inferred from page(s)

published in

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21 January 2020

volume

285

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21 January 2020

issue

21

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21 January 2020

page(s)

16315-16329

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The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function

21 January 2020

cites work

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Identification of protein domains that control proton and calcium sensitivity of ASIC1a

14 July 2018

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Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

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Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

14 July 2018

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Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels

14 July 2018

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ASIC3, a sensor of acidic and primary inflammatory pain

14 July 2018

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Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.

14 July 2018

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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

14 July 2018

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A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.

14 July 2018

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14 July 2018

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14 July 2018

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Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia

14 July 2018

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Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism

14 July 2018

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Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli.

14 July 2018

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Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating

14 July 2018

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Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

14 July 2018

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14 July 2018

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Selective regulation of acid-sensing ion channel 1 by serine proteases

14 July 2018

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The ASICs: signaling molecules? Modulators?

14 July 2018

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Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade

14 July 2018

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Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

14 July 2018

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The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory

14 July 2018

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Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons

14 July 2018

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Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b

14 July 2018

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Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

14 July 2018

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pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits

21 January 2018

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Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).

21 January 2018

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Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.

21 January 2018

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Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a.

21 January 2018

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21 January 2018

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21 January 2018

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Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating

21 January 2018

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Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

21 January 2018

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Zn2+ and H+ are coactivators of acid-sensing ion channels

21 January 2018

1 reference

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Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel

21 January 2018

1 reference

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Novel knowledge-based mean force potential at atomic level

21 January 2018

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Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

21 January 2018

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26 November 2018

Identifiers

DOI

10.1074/JBC.M109.092015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20299463%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20299463%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

20299463

1 reference