Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism (Q30495859)

17 October 2017

Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism (English)

1 reference

17 October 2017

foot-and-mouth disease

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foot-and-mouth disease virus

inferred from title

Foot-and-mouth disease virus

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6

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17 October 2017

7

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17 October 2017

8

Stephen Curry

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Daniel Bose

Daniel Bose

3

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Trevor R Sweeney

Trevor R Sweeney

1

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Jon R Wilson

Jon R Wilson

5

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author name string

Valentina Cisnetto

2

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PMCID

2915670

17 October 2017

Matthew Bailey

4

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PMCID

2915670

17 October 2017

language of work or name

English

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publication date

27 May 2010

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Journal of Biological Chemistry

17 October 2017

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17 October 2017

285

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17 October 2017

24347-24359

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17 October 2017

32

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Poliovirus 2C Protein Forms Homo-oligomeric Structures Required for ATPase Activity

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Modification of intracellular membrane structures for virus replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Dynamics of picornavirus RNA replication within infected cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Structure and mechanism of helicases and nucleic acid translocases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Inhibition of the secretory pathway by foot-and-mouth disease virus 2BC protein is reproduced by coexpression of 2B with 2C, and the site of inhibition is determined by the subcellular location of 2C.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Mechanism of DNA translocation in a replicative hexameric helicase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Evidence for functional protein interactions required for poliovirus RNA replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Evolutionary relationships and structural mechanisms of AAA+ proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-Golgi transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Binding and unwinding: SF3 viral helicases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

20 June 2018

Foot-and-mouth disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The ultrastructure of the developing replication site in foot-and-mouth disease virus-infected BHK-38 cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Evolutionary history and higher order classification of AAA+ ATPases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The crystal structure of the bifunctional primase-helicase of bacteriophage T7

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Crystal structures of fusion proteins with large-affinity tags

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Molecular basis of pathogenesis of FMDV.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

High-throughput screening of soluble recombinant proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Proteome-scale purification of human proteins from bacteria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Rapid screening for improved solubility of small human proteins produced as fusion proteins in Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Structure of the AAA ATPase p97

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Polypeptide p41 of a Norwalk-like virus is a nucleic acid-independent nucleoside triphosphatase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Protein production: feeding the crystallographers and NMR spectroscopists

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Echovirus-9 protein 2C binds single-stranded RNA unspecifically

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: the significance of viral protein 2C

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Amino-terminal region of poliovirus 2C protein is sufficient for membrane binding.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Poliovirus-encoded 2C polypeptide specifically binds to the 3'-terminal sequences of viral negative-strand RNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Cellular origin and ultrastructure of membranes induced during poliovirus infection

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

A new generation of the IMAGIC image processing system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The portal protein of bacteriophage SPP1: a DNA pump with 13-fold symmetry.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Poliovirus protein 2C has ATPase and GTPase activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Biochemical studies on poliovirus polypeptide 2C: evidence for ATPase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Poliovirus protein 2C contains two regions involved in RNA binding activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Guanidine-resistant mutants of aphthovirus induce the synthesis of an altered nonstructural polypeptide, P34.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

The malachite green micromethod for the determination of inorganic phosphate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Guanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2C

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Recombination and oligonucleotide analysis of guanidine-resistant foot-and-mouth disease virus mutants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915670

Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Membrane association and RNA binding of recombinant hepatitis A virus protein 2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Amino acid substitutions within the 2C coding sequence of Theiler's Murine Encephalomyelitis virus alter virus growth and affect protein distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

ATP hydrolysis and AMP kinase activities of nonstructural protein 2C of human parechovirus 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Microassay of phosphate provides a general method for measuring the activity of phosphatases using physiological, nonchromogenic substrates such as lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

ATP-dependent transcriptional activation by bacterial PspF AAA+protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Assembly of a double hexameric helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Interaction of picornavirus 2C polypeptide with the viral negative-strand RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Structure and RNA Interactions of the N-Terminal RRM Domains of PTB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Structural studies of the archaeal MCM complex in different functional states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129940

Echovirus 9 strain barty non-structural protein 2C has NTPase activity

21 January 2018

1 reference

12 December 2020

Interaction of poliovirus-encoded 2C/2BC polypeptides with the 3' terminus negative-strand cloverleaf requires an intact stem-loop b

1 reference

12 December 2020

Genetic analysis of an NTP-binding motif in poliovirus polypeptide 2C

1 reference

12 December 2020

Membrane rearrangement and vesicle induction by recombinant poliovirus 2C and 2BC in human cells

1 reference

12 December 2020

Amino terminal regions of poliovirus 2C protein mediate membrane binding

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.129940

1 reference

17 October 2017

1 reference

17 October 2017

1 reference

PMCID

2915670