The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase (Q30497031)

13 October 2017

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase (English)

1 reference

13 October 2017

Piyawan Bunpo

1

1 reference

13 October 2017

Judy K Cundiff

2

1 reference

13 October 2017

Rachel B Reinert

3

1 reference

13 October 2017

Ronald C Wek

4

1 reference

13 October 2017

Carla J Aldrich

5

1 reference

13 October 2017

Tracy G Anthony

6

1 reference

13 October 2017

language of work or name

English

0 references

publication date

22 September 2010

1 reference

13 October 2017

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13 October 2017

140

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13 October 2017

2020-2027

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13 October 2017

11

1 reference

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

ATF4-dependent transcription mediates signaling of amino acid limitation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Treatment of acute lymphoblastic leukemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Coping with stress: eIF2 kinases and translational control

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The thymus: a barometer of malnutrition.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine requirement of proliferating T lymphocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Enzyme-induced asparagine and glutamine depletion and immune system function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The essential role of L-glutamine in lymphocyte differentiation in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Asparaginase-induced derangements of glutamine metabolism: the pathogenetic basis for some drug-related side-effects.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

The inhibition of lymphocyte blastogenesis by asparaginase: critical role of glutamine in both T and B lymphocyte transformation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells

20 June 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3945%2FJN.110.129197

Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2955878

Alteration in spleen lymphoid populations associated with specific amino acid depletion during L-asparaginase treatment

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20861212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20861212

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3945/JN.110.129197

1 reference

13 October 2017

1 reference

13 October 2017

1 reference