Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment. (Q30497743)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135224%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment (English)

1 reference

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17 January 2020

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1

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17 January 2020

2

Ronald D Vale

1 reference

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17 January 2020

language of work or name

English

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publication date

6 December 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135224%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

17 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135224%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

107

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page(s)

22128-22133

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issue

51

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describes a project that uses

17 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3009781/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

1 reference

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Endosomes: a legitimate platform for the signaling train

20 June 2018

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Signaling from endosomes: location makes a difference.

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

20 June 2018

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

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Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

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Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling

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ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

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Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

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Constitutive and ligand-induced TCR degradation.

20 June 2018

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

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Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels

21 January 2018

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Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

21 January 2018

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Signaling on the endocytic pathway

21 January 2018

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A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization.

21 January 2018

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A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation

21 January 2018

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Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes.

21 January 2018

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Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

26 November 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1016388108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21135224%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

1 reference

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17 January 2020

1 reference