Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog (Q30500428)

19 October 2017

Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog (English)

1 reference

19 October 2017

Hui Li

1

1 reference

19 October 2017

Shu Wang

2

1 reference

19 October 2017

Alexander Y Chuang

3

1 reference

19 October 2017

Bruce E Cohen

4

1 reference

19 October 2017

Huai-Hu Chuang

5

1 reference

19 October 2017

language of work or name

English

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publication date

2 May 2011

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Proceedings of the National Academy of Sciences of the United States of America

19 October 2017

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19 October 2017

108

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19 October 2017

20

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19 October 2017

8497-8502

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Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Non-junction functions of pannexin-1 channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Pore dilation occurs in TRPA1 but not in TRPM8 channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Tunable calcium current through TRPV1 receptor channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

TRPV1 shows dynamic ionic selectivity during agonist stimulation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Voltage is a partial activator of rat thermosensitive TRP channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

TRPV1 acts as proton channel to induce acidification in nociceptive neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Induction of vanilloid receptor channel activity by protein kinase C

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Vanilloid (Capsaicin) receptors and mechanisms

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Pore dilation of neuronal P2X receptor channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The cloned capsaicin receptor integrates multiple pain-producing stimuli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The capsaicin receptor: a heat-activated ion channel in the pain pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Molecular basis for species-specific sensitivity to "hot" chili peppers

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region".

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Nitric oxide activates TRP channels by cysteine S-nitrosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Autocrine purinergic receptor signaling is essential for macrophage chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Channel-mediated tonic GABA release from glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018550108

Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100990

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

26 November 2018

1 reference

12 December 2020

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region"

1 reference

12 December 2020

Substance P release from spinal cord slices by capsaicin

1 reference

12 December 2020

Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation

1 reference

12 December 2020

Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats

1 reference

12 December 2020

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1018550108

1 reference

19 October 2017

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1 reference

19 October 2017

1 reference