IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. (Q30500880)

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English	IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.	scientific article

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20 January 2020

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation (English)

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20 January 2020

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ChEBI release 2020-05-28

apoptotic process

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David M. Virshup

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20 January 2020

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20 January 2020

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J K Cheong

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20 January 2020

T H Nguyen

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20 January 2020

P Tan

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20 January 2020

P M Voorhoeve

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20 January 2020

S H Lee

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24 January 2011

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20 January 2020

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20 January 2020

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20 January 2020

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20 January 2020

2558-2569

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20 January 2020

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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

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Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest

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Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

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Human cancer cells commonly acquire DNA damage during mitotic arrest

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Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

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CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

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The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development

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20 June 2018

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Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.

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1 reference

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10.1038/ONC.2010.627

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20 January 2020

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20 January 2020

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20 January 2020

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