Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5 (Q30500964)

1 September 2017

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5 (English)

1 reference

1 September 2017

6

William L Klein

1 reference

1 September 2017

Marianne Renner

1

1 reference

1 September 2017

Pascale N Lacor

2

1 reference

1 September 2017

Pauline T Velasco

3

1 reference

1 September 2017

Jian Xu

4

1 reference

1 September 2017

Anis Contractor

5

1 reference

1 September 2017

Antoine Triller

7

1 reference

1 September 2017

language of work or name

English

0 references

publication date

1 June 2010

1 reference

1 September 2017

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1 September 2017

66

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1 September 2017

739-754

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1 September 2017

5

1 reference

describes a project that uses

1 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3111138/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway.

20 June 2018

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Advances on the understanding of the origins of synaptic pathology in AD.

20 June 2018

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mGluR5 has a critical role in inhibitory learning.

20 June 2018

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

20 June 2018

1 reference

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

20 June 2018

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A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

20 June 2018

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mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex

20 June 2018

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Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction

20 June 2018

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Molecular dynamics of postsynaptic receptors and scaffold proteins

20 June 2018

1 reference

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Structural classification of toxic amyloid oligomers

20 June 2018

1 reference

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New concepts in synaptic biology derived from single-molecule imaging

20 June 2018

1 reference

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

20 June 2018

1 reference

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Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

20 June 2018

1 reference

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Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

20 June 2018

1 reference

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Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

20 June 2018

1 reference

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Metabotropic glutamate receptors: synaptic modulators and therapeutic targets for neurologic disease

20 June 2018

1 reference

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Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

20 June 2018

1 reference

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Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors

20 June 2018

1 reference

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Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity

20 June 2018

1 reference

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Imaging the lateral diffusion of membrane molecules with quantum dots

20 June 2018

1 reference

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

20 June 2018

1 reference

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

20 June 2018

1 reference

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

20 June 2018

1 reference

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Astrocyte control of synaptic transmission and neurovascular coupling.

20 June 2018

1 reference

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The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides

20 June 2018

1 reference

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Regulation of NMDA receptor trafficking by amyloid-beta

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

20 June 2018

1 reference

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Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking

20 June 2018

1 reference

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Alzheimer's disease is a synaptic failure

20 June 2018

1 reference

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

20 June 2018

1 reference

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Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Control of the postsynaptic membrane viscosity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Monoclonal antibodies that target pathological assemblies of Abeta.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Divergent effects of Abeta1-42 on ionotropic glutamate receptor-mediated responses in CA1 neurons in vivo.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Self-assembly of Abeta(1-42) into globular neurotoxins.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111138

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20547131

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2010.04.029

1 reference

1 September 2017

1 reference

1 September 2017

1 reference