Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking (Q30502320)

10 August 2017

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking (English)

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10 August 2017

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Pia Steensland

1

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author name string

Jeffrey A Simms

2

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10 August 2017

Joan Holgate

3

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10 August 2017

Jemma K Richards

4

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10 August 2017

Selena E Bartlett

5

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10 August 2017

language of work or name

English

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publication date

11 July 2007

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Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

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10 August 2017

104

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10 August 2017

30

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10 August 2017

12518-12523

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Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Alcohol's actions on neuronal nicotinic acetylcholine receptors.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Nicotine addiction and comorbidity with alcohol abuse and mental illness

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Posttreatment results of combining naltrexone with cognitive-behavior therapy for the treatment of alcoholism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Nicotinic receptors in the brain: correlating physiology with function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Neuronal nicotinic acetylcholine receptors: a new target site of ethanol

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Ethanol modulation of nicotinic acetylcholine receptor currents in cultured cortical neurons.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Identification of four classes of brain nicotinic receptors using beta2 mutant mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Naltrexone blocks the post-shock increase of ethanol consumption

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Naltrexone in the treatment of alcohol dependence

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Alteration of ethanol self-administration by naltrexone.

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Involvement of nicotinic receptors in alcohol self-administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Mecamylamine and ethanol preference in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

In alcohol-treated rats, naloxone decreases extracellular dopamine and increases acetylcholine in the nucleus accumbens: evidence of opioid withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Potential regulation of nicotine and ethanol actions by alpha4-containing nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Interaction of the Nicotinic Cholinergic System with Ethanol Withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

The effect of chronic ethanol administration of high affinity 3H-nicotinic binding in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Ethanol modulates nicotine-induced upregulation of nAChRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

A double-blind study evaluating the long-term safety of varenicline for smoking cessation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Hypericum perforatum CO2 Extract and Opioid Receptor Antagonists Act Synergistically to Reduce Ethanol Intake in Alcohol‐Preferring Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705368104

Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Heavy consumption of cigarettes, alcohol and coffee in male twins.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914040

Voluntary ethanol intake in rats following exposure to ethanol on various schedules

26 November 2018

1 reference

12 December 2020

Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference

1 reference

12 December 2020

Naltrexone and coping skills therapy for alcohol dependence. A controlled study

1 reference

12 December 2020

Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment

1 reference

12 December 2020

Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats

1 reference

12 December 2020

Naltrexone as an adjunctive treatment for older patients with alcohol dependence

1 reference

12 December 2020

Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of ethanol

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0705368104

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10 August 2017

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10 August 2017

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