Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease (Q30512697)

10 August 2017

Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease (English)

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10 August 2017

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Oliver Wirths

9

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Henrik Zetterberg

3

object named as

Henrik Zetterberg

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10 August 2017

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Kaj Blennow

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10 August 2017

2

Erik Portelius

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10 August 2017

Jessica L Wittnam

1

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10 August 2017

Mikael K Gustavsson

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10 August 2017

Stephan Schilling

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10 August 2017

Birgit Koch

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10 August 2017

Hans-Ulrich Demuth

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10 August 2017

Thomas A Bayer

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10 August 2017

language of work or name

English

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publication date

20 January 2012

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Journal of Biological Chemistry

10 August 2017

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10 August 2017

287

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10 August 2017

11

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10 August 2017

8154-8162

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3318696/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

20 June 2018

1 reference

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Potent amyloidogenicity and pathogenicity of Aβ43.

20 June 2018

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Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

20 June 2018

1 reference

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Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

20 June 2018

1 reference

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

20 June 2018

1 reference

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Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease

20 June 2018

1 reference

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

20 June 2018

1 reference

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High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

20 June 2018

1 reference

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

20 June 2018

1 reference

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Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain

20 June 2018

1 reference

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Differences between vascular and plaque core amyloid in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Amyloid plaque core protein in Alzheimer disease and Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

beta-amyloid is different in normal aging and in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.308601

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318696

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22267726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22267726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.308601

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22267726

1 reference