Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. (Q30522343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711878%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype (English)

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5 February 2020

0 references

1 reference

2

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5 February 2020

Malin E. V. Johansson

4

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5 February 2020

Harriet Nilsson

5

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5 February 2020

Kaisa Thorell

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5 February 2020

Gunnar C Hansson

9

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5 February 2020

author name string

Jenny K Gustafsson

1

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5 February 2020

Daniel Ambort

3

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5 February 2020

Hans Hebert

7

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5 February 2020

Henrik Sjövall

8

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5 February 2020

language of work or name

English

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publication date

18 June 2012

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Journal of Experimental Medicine

5 February 2020

published in

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5 February 2020

volume

209

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5 February 2020

issue

7

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5 February 2020

page(s)

1263-1272

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Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

5 February 2020

cites work

1 reference

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An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.

20 June 2018

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Composition and functional role of the mucus layers in the intestine

20 June 2018

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Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia

20 June 2018

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Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine

20 June 2018

1 reference

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Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

20 June 2018

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Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion

20 June 2018

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Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

20 June 2018

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von Willebrand factor assembly and secretion

20 June 2018

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

20 June 2018

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Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

20 June 2018

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Gel-forming mucins appeared early in metazoan evolution.

20 June 2018

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Structure and function of the polymeric mucins in airways mucus.

20 June 2018

1 reference

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The underlying cellular mechanism in the effect of tetramethylpyrazine on the anion secretion of colonic mucosa

20 June 2018

1 reference

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Assembly of functional CFTR chloride channels

20 June 2018

1 reference

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Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine

20 June 2018

1 reference

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Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

20 June 2018

1 reference

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Small-scale analysis of O-linked oligosaccharides from glycoproteins and mucins separated by gel electrophoresis

20 June 2018

1 reference

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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

20 June 2018

1 reference

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The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

20 June 2018

1 reference

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Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase

20 June 2018

1 reference

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Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum

20 June 2018

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Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis

20 June 2018

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Pathophysiology of gene-targeted mouse models for cystic fibrosis

20 June 2018

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Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

20 June 2018

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A mouse model for the cystic fibrosis delta F508 mutation.

20 June 2018

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Chloride impermeability in cystic fibrosis

20 June 2018

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

20 June 2018

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T84 cells: anion selectivity demonstrates expression of Cl- conductance affected in cystic fibrosis

20 June 2018

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A new role for bicarbonate secretion in cervico-uterine mucus release

20 June 2018

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Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression.

26 November 2018

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Inflammation of the cystic fibrosis mouse small intestine

26 November 2018

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Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries

26 November 2018

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Involvement of inwardly rectifying K+ channels in secretory responses of human ileal mucosa

26 November 2018

1 reference

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Mucus glycoproteins from pig gastric mucosa: identification ofdifferent mucin populations from the surface epithelium.

26 November 2018

1 reference

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26 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22711878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22711878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22711878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20120562

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711878%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711878%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22711878

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711878%20AND%20SRC:MED&resulttype=core&format=json