Synthetic spatially graded Rac activation drives cell polarization and movement (Q30531107)

14 August 2017

Synthetic spatially graded Rac activation drives cell polarization and movement (English)

1 reference

14 August 2017

6

Leah Edelstein-Keshet

1 reference

14 August 2017

Benjamin Lin

1

1 reference

14 August 2017

William R Holmes

2

1 reference

14 August 2017

C Joanne Wang

3

1 reference

14 August 2017

Tasuku Ueno

4

1 reference

14 August 2017

Andrew Harwell

5

1 reference

14 August 2017

Takanari Inoue

7

1 reference

14 August 2017

Andre Levchenko

8

1 reference

14 August 2017

language of work or name

English

0 references

publication date

26 November 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

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14 August 2017

109

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14 August 2017

52

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14 August 2017

E3668-77

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How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Development of an optimized backbone of FRET biosensors for kinases and GTPases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Chemotactic cell trapping in controlled alternating gradient fields

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Chemically controlled protein assembly: techniques and applications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Biosensors for characterizing the dynamics of rho family GTPases in living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Induction of protein-protein interactions in live cells using light

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Spatiotemporal control of cell signalling using a light-switchable protein interaction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A genetically encoded photoactivatable Rac controls the motility of living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Moving towards a better understanding of chemotaxis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Polar stimulation and constrained cell migration in microfluidic channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Bound attractant at the leading vs. the trailing edge determines chemotactic prowess

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Spatiotemporal dynamics of RhoA activity in migrating cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Chemical rescue of a mutant enzyme in living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Characterization of the FKBP.rapamycin.FRB ternary complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Activation of endogenous Cdc42 visualized in living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Cofilin promotes actin polymerization and defines the direction of cell motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Cell migration: integrating signals from front to back

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Localized Rac activation dynamics visualized in living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A chemical switch for inhibitor-sensitive alleles of any protein kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Monolithic microfabricated valves and pumps by multilayer soft lithography

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Turning of nerve growth cones induced by localized increases in intracellular calcium ions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A cell's sense of direction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Rho GTPases and the actin cytoskeleton

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

A humanized system for pharmacologic control of gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535611

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

Dynamic single cell culture array

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

Efficient subpixel image registration algorithms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

Chemotaxis in the Absence of PIP3 Gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1210295109

The collection of the motile population of cells from a living tumor

21 January 2018

1 reference

12 December 2020

G protein signaling events are activated at the leading edge of chemotactic cells

1 reference

12 December 2020

A membrane-permeant ester of phosphatidylinositol 3,4, 5-trisphosphate (PIP(3)) is an activator of human neutrophil migration

1 reference

12 December 2020

Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device

1 reference

12 December 2020

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1210295109

1 reference

14 August 2017

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1 reference

1 reference

14 August 2017

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