Genetic mouse models of parkinsonism: strengths and limitations (Q30537732)

8 November 2017

1 reference

title

Genetic mouse models of parkinsonism: strengths and limitations (English)

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8 November 2017

2 references

parkinsonian syndrome

1 reference

Marie-Françoise Chesselet

inferred from title

author

series ordinal

3

object named as

Marie-Françoise Chesselet

1 reference

8 November 2017

Sheila M Fleming

1

1 reference

PMC publication ID

1144493

8 November 2017

Pierre-Olivier Fernagut

series ordinal

2

1 reference

8 November 2017

1 July 2005

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8 November 2017

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8 November 2017

2

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8 November 2017

3

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8 November 2017

495-503

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

8 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Parkin-deficient mice are not a robust model of parkinsonism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Loss of locus coeruleus neurons and reduced startle in parkin null mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

alpha-Synuclein locus triplication causes Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Pitx3 is required for development of substantia nigra dopaminergic neurons.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mutations in NR4A2 associated with familial Parkinson disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Lewy bodies and parkinsonism in families with parkin mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Association between early-onset Parkinson's disease and mutations in the parkin gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Usefulness of a dopamine transporter PET ligand [(18)F]beta-CFT in assessing disability in Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Identification and characterization of a novel protein that regulates RNA-protein interaction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Dopamine neuron agenesis in Nurr1-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Familial juvenile parkinsonism: clinical and pathologic study in a family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Identification of a new brain-specific transcription factor, NURR1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Disease-specific patterns of locus coeruleus cell loss

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

20 June 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Idiopathic hyposmia as a preclinical sign of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Role of alpha-synuclein in presynaptic dopamine recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

The neurological mutant quaking(viable) is Parkin deficient

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

The role of pathogenic DJ-1 mutations in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Age-dependent dopaminergic dysfunction in Nurr1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

alpha-synuclein gene haplotypes are associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.3.495

Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1144493

Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease

26 November 2018

1 reference

12 December 2020

Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury

1 reference

12 December 2020

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

1 reference

12 December 2020

Neuropathology in mice expressing human alpha-synuclein

1 reference

12 December 2020

An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene.

1 reference

12 December 2020

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

1 reference

12 December 2020

Dopaminergic brain system in the quaking mutant mouse

1 reference

12 December 2020

Early diagnosis of Parkinson's disease

1 reference

12 December 2020

Identifiers

DOI

10.1602/NEURORX.2.3.495

1 reference

8 November 2017

1 reference

PMC publication ID

1144493

8 November 2017

PubMed publication ID

16389313

1 reference

PMC publication ID

1144493