Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering (Q30566719)

20 August 2017

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering (English)

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20 August 2017

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11

Maiken Nedergaard

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Erlend A. Nagelhus

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object named as

Erlend A Nagelhus

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20 August 2017

Vinita Rangroo Thrane

1

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20 August 2017

Alexander S Thrane

2

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20 August 2017

Fushun Wang

3

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20 August 2017

Maria L Cotrina

4

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20 August 2017

Nathan A Smith

5

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20 August 2017

Michael Chen

6

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20 August 2017

Qiwu Xu

7

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20 August 2017

Ning Kang

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20 August 2017

Takumi Fujita

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20 August 2017

language of work or name

English

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publication date

17 November 2013

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20 August 2017

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20 August 2017

19

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20 August 2017

12

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20 August 2017

1643-1648

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Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Ammonia production, excretion, toxicity, and defense in fish: a review

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

13N as a tracer for studying glutamate metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Na-K-Cl Cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Imaging large-scale neural activity with cellular resolution in awake, mobile mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Hyperammonemia-induced toxicity for the developing central nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Cortical spreading depression causes and coincides with tissue hypoxia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

NKCC1 transporter facilitates seizures in the developing brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Pathophysiology of hepatic encephalopathy: a new look at ammonia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Adenovirus-mediated in vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Ion-selective microelectrodes and diffusion measurements as tools to explore the brain cell microenvironment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

An enzymatic determination of ammonia in biological fluids.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Effect of ammonium ions on synaptic transmission in the mammalian central nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Disinhibition in cat motor cortex by ammonia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Effects of ammonium ions on spontaneous action potentials and on contents of sodium, potassium, ammonium and chloride ions in brain in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Glutamine Synthetase: Glial Localization in Brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Neuron-glial trafficking of NH4+ and K+: separate routes of uptake into glial cells of bee retina.

20 June 2018

1 reference

Risk factors for hyperammonemia in pediatric patients with epilepsy.

21 January 2018

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Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ.

21 January 2018

1 reference

GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.

21 January 2018

1 reference

Facilitating sensory responses in developing mouse somatosensory barrel cortex.

21 January 2018

1 reference

Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf.

21 January 2018

1 reference

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

21 January 2018

1 reference

Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

21 January 2018

1 reference

Memory for context becomes less specific with time

21 January 2018

1 reference

Taurine activates excitatory non-synaptic glycine receptors on dopamine neurones in ventral tegmental area of young rats

21 January 2018

1 reference

Gap-junction-mediated propagation and amplification of cell injury.

21 January 2018

1 reference

Comparison of Na-K ATPase activity in rat brain synaptosome under various conditions.

21 January 2018

1 reference

Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899396

Na+,K(+)-ATPase activities are increased in brain in both congenital and acquired hyperammonemic syndromes

26 November 2018

1 reference

12 December 2020

The differential expression patterns of messenger RNAs encoding K-Cl cotransporters (KCC1,2) and Na-K-2Cl cotransporter (NKCC1) in the rat nervous system

1 reference

12 December 2020

NH+4 transport mediated by Na(+)-K(+)-ATPase in rat inner medullary collecting duct

1 reference

12 December 2020

Ammonium and Chloride Extrusion: Hyperpolarizing Synaptic Inhibition in Spinal Motoneurons

1 reference

12 December 2020

Ammonia and disinhibition in cat motor cortex by ammonium acetate, monofluoroacetate and insulin-induced hypoglycemia

1 reference

12 December 2020

Physiological levels of ammonia regulate glutamine synthesis from extracellular glutamate in astrocyte cultures

1 reference

12 December 2020

Ionic composition of cisternal CSF in acute respiratory acidosis: lack of effect of large dose bumetanide

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3400

1 reference

20 August 2017

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20 August 2017

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