Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium (Q30574557)

21 August 2017

Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium (English)

1 reference

21 August 2017

Amy Reynolds

1

1 reference

21 August 2017

Natalia Wharton

2

1 reference

21 August 2017

Alyson Parris

3

1 reference

21 August 2017

Esther Mitchell

4

1 reference

21 August 2017

Anastasia Sobolewski

5

1 reference

21 August 2017

Christy Kam

6

1 reference

21 August 2017

Loren Bigwood

7

1 reference

21 August 2017

Ahmed El Hadi

8

1 reference

21 August 2017

Andrea Münsterberg

9

1 reference

21 August 2017

Michael Lewis

10

1 reference

21 August 2017

Christopher Speakman

11

1 reference

21 August 2017

William Stebbings

12

1 reference

21 August 2017

Richard Wharton

13

1 reference

21 August 2017

Kevin Sargen

14

1 reference

21 August 2017

Richard Tighe

15

1 reference

21 August 2017

Crawford Jamieson

16

1 reference

21 August 2017

James Hernon

17

1 reference

21 August 2017

Sandeep Kapur

18

1 reference

21 August 2017

Naohide Oue

19

1 reference

21 August 2017

Wataru Yasui

20

1 reference

21 August 2017

Mark R Williams

21

1 reference

21 August 2017

language of work or name

English

0 references

publication date

5 July 2013

1 reference

21 August 2017

1 reference

21 August 2017

63

1 reference

21 August 2017

4

1 reference

21 August 2017

610-621

1 reference

describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3963552/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Stem cells, self-renewal, and differentiation in the intestinal epithelium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Current view: intestinal stem cells and signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Identification of stem cells in small intestine and colon by marker gene Lgr5

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Intestinal stem cell replacement follows a pattern of neutral drift

20 June 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Isolation and in vitro expansion of human colonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

In situ validation of an intestinal stem cell signature in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Wnt and BMP signals control intestinal adenoma cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2012-304067

Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3963552

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23831735

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1136/GUTJNL-2012-304067

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

23831735

1 reference